Improved synthesis of the iodine-free thyromimetic GC-1

Grazia Chiellini, Ngoc Ha Nguyen, Hikari A.I. Yoshihara, Thomas S. Scanlan

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Synthesis of the TRβ-selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2607-2611
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number23
DOIs
StatePublished - Dec 4 2000

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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