Improved synthesis of the iodine-free thyromimetic GC-1

Grazia Chiellini; Ngoc Ha Nguyen; Hikari A.I. Yoshihara; Thomas S. Scanlan

doi:10.1016/S0960-894X(00)00531-X

Improved synthesis of the iodine-free thyromimetic GC-1

Grazia Chiellini, Ngoc Ha Nguyen, Hikari A.I. Yoshihara, Thomas S. Scanlan

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Synthesis of the TRβ-selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	2607-2611
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(00)00531-X
State	Published - Dec 4 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00531-X

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abstract = "Synthesis of the TRβ-selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design. (C) 2000 Elsevier Science Ltd.",

author = "Grazia Chiellini and Nguyen, {Ngoc Ha} and Yoshihara, {Hikari A.I.} and Scanlan, {Thomas S.}",

note = "Funding Information: This work was supported by a grant from the National Institutes of Health (DK 52798). T.S.S. is an Alfred P. Sloan Research Fellow.",

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AU - Chiellini, Grazia

AU - Nguyen, Ngoc Ha

AU - Yoshihara, Hikari A.I.

AU - Scanlan, Thomas S.

N1 - Funding Information: This work was supported by a grant from the National Institutes of Health (DK 52798). T.S.S. is an Alfred P. Sloan Research Fellow.

PY - 2000/12/4

Y1 - 2000/12/4

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Improved synthesis of the iodine-free thyromimetic GC-1

Abstract

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