Importance of pre-treatment radiation absorbed dose estimation for radioimmunotherapy of non-Hodgkin's lymphoma

Janet F. Eary, Kenneth Krohn, Oliver W. Press, Lawrence Durack, Irwin D. Bernstein

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Non-Hodgkin's lymphoma 1-131 radioimmunotherapy data were analyzed to determine whether a predictive relationship exists between radiation absorbed doses calculated from biodistribution studies and doses derived from patient size. Radioactivity treatment administrations scaled to patient size (MBq/kg or MBq/m2) or fixed MBq doses do not produce consistent radiation absorbed dose to critical organs. Treatment trials that do not provide dose estimates for critical normal organs are less likely to succeed in identifying a clinical role for radioimmunotherapy.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalNuclear Medicine and Biology
Volume24
Issue number7
DOIs
StatePublished - Oct 1997
Externally publishedYes

Fingerprint

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Radiation
Radioactivity
Therapeutics

Keywords

  • Dose estimation
  • I-131
  • Non-Hodgkin's lymphoma
  • Radioimmunotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Importance of pre-treatment radiation absorbed dose estimation for radioimmunotherapy of non-Hodgkin's lymphoma. / Eary, Janet F.; Krohn, Kenneth; Press, Oliver W.; Durack, Lawrence; Bernstein, Irwin D.

In: Nuclear Medicine and Biology, Vol. 24, No. 7, 10.1997, p. 635-638.

Research output: Contribution to journalArticle

Eary, Janet F. ; Krohn, Kenneth ; Press, Oliver W. ; Durack, Lawrence ; Bernstein, Irwin D. / Importance of pre-treatment radiation absorbed dose estimation for radioimmunotherapy of non-Hodgkin's lymphoma. In: Nuclear Medicine and Biology. 1997 ; Vol. 24, No. 7. pp. 635-638.
@article{3ba7409ab5d94d9c923dbe80ab0f49f8,
title = "Importance of pre-treatment radiation absorbed dose estimation for radioimmunotherapy of non-Hodgkin's lymphoma",
abstract = "Non-Hodgkin's lymphoma 1-131 radioimmunotherapy data were analyzed to determine whether a predictive relationship exists between radiation absorbed doses calculated from biodistribution studies and doses derived from patient size. Radioactivity treatment administrations scaled to patient size (MBq/kg or MBq/m2) or fixed MBq doses do not produce consistent radiation absorbed dose to critical organs. Treatment trials that do not provide dose estimates for critical normal organs are less likely to succeed in identifying a clinical role for radioimmunotherapy.",
keywords = "Dose estimation, I-131, Non-Hodgkin's lymphoma, Radioimmunotherapy",
author = "Eary, {Janet F.} and Kenneth Krohn and Press, {Oliver W.} and Lawrence Durack and Bernstein, {Irwin D.}",
year = "1997",
month = "10",
doi = "10.1016/S0969-8051(97)00098-X",
language = "English (US)",
volume = "24",
pages = "635--638",
journal = "International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology",
issn = "0969-8051",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Importance of pre-treatment radiation absorbed dose estimation for radioimmunotherapy of non-Hodgkin's lymphoma

AU - Eary, Janet F.

AU - Krohn, Kenneth

AU - Press, Oliver W.

AU - Durack, Lawrence

AU - Bernstein, Irwin D.

PY - 1997/10

Y1 - 1997/10

N2 - Non-Hodgkin's lymphoma 1-131 radioimmunotherapy data were analyzed to determine whether a predictive relationship exists between radiation absorbed doses calculated from biodistribution studies and doses derived from patient size. Radioactivity treatment administrations scaled to patient size (MBq/kg or MBq/m2) or fixed MBq doses do not produce consistent radiation absorbed dose to critical organs. Treatment trials that do not provide dose estimates for critical normal organs are less likely to succeed in identifying a clinical role for radioimmunotherapy.

AB - Non-Hodgkin's lymphoma 1-131 radioimmunotherapy data were analyzed to determine whether a predictive relationship exists between radiation absorbed doses calculated from biodistribution studies and doses derived from patient size. Radioactivity treatment administrations scaled to patient size (MBq/kg or MBq/m2) or fixed MBq doses do not produce consistent radiation absorbed dose to critical organs. Treatment trials that do not provide dose estimates for critical normal organs are less likely to succeed in identifying a clinical role for radioimmunotherapy.

KW - Dose estimation

KW - I-131

KW - Non-Hodgkin's lymphoma

KW - Radioimmunotherapy

UR - http://www.scopus.com/inward/record.url?scp=0030761910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030761910&partnerID=8YFLogxK

U2 - 10.1016/S0969-8051(97)00098-X

DO - 10.1016/S0969-8051(97)00098-X

M3 - Article

VL - 24

SP - 635

EP - 638

JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

SN - 0969-8051

IS - 7

ER -