Importance of pre-treatment radiation absorbed dose estimation for radioimmunotherapy of non-Hodgkin's lymphoma

Janet F. Eary, Kenneth A. Krohn, Oliver W. Press, Lawrence Durack, Irwin D. Bernstein

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Non-Hodgkin's lymphoma 1-131 radioimmunotherapy data were analyzed to determine whether a predictive relationship exists between radiation absorbed doses calculated from biodistribution studies and doses derived from patient size. Radioactivity treatment administrations scaled to patient size (MBq/kg or MBq/m2) or fixed MBq doses do not produce consistent radiation absorbed dose to critical organs. Treatment trials that do not provide dose estimates for critical normal organs are less likely to succeed in identifying a clinical role for radioimmunotherapy.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalNuclear Medicine and Biology
Volume24
Issue number7
DOIs
StatePublished - Oct 1 1997

Keywords

  • Dose estimation
  • I-131
  • Non-Hodgkin's lymphoma
  • Radioimmunotherapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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