TY - JOUR
T1 - Implantable diagnostic device for cancer monitoring
AU - Daniel, Karen D.
AU - Kim, Grace Y.
AU - Vassiliou, Christophoros C.
AU - Galindo, Marilyn
AU - Guimaraes, Alexander R.
AU - Weissleder, Ralph
AU - Charest, Al
AU - Langer, Robert
AU - Cima, Michael J.
N1 - Funding Information:
This work was supported by NCI Centers of Cancer Nanotechnology Excellence No. 5 U54 CA119349-12 grant and NSF Division of Materials Research Award No. 0746264. We would like to acknowledge Stephen Woolfenden for assistance with in vivo studies and Lee Josephson at CMIR for assistance with MRSw.
PY - 2009/7/15
Y1 - 2009/7/15
N2 - Biopsies provide required information to diagnose cancer but, because of their invasiveness, they are difficult to use for managing cancer therapy. The ability to repeatedly sample the local environment for tumor biomarker, chemotherapeutic agent, and tumor metabolite concentrations could improve early detection of metastasis and personalized therapy. Here we describe an implantable diagnostic device that senses the local in vivo environment. This device, which could be left behind during biopsy, uses a semi-permeable membrane to contain nanoparticle magnetic relaxation switches. A cell line secreting a model cancer biomarker produced ectopic tumors in mice. The transverse relaxation time (T2) of devices in tumor-bearing mice was 20 ± 10% lower than devices in control mice after 1 day by magnetic resonance imaging (p < 0.01). Short term applications for this device are numerous, including verification of successful tumor resection. This may represent the first continuous monitoring device for soluble cancer biomarkers in vivo.
AB - Biopsies provide required information to diagnose cancer but, because of their invasiveness, they are difficult to use for managing cancer therapy. The ability to repeatedly sample the local environment for tumor biomarker, chemotherapeutic agent, and tumor metabolite concentrations could improve early detection of metastasis and personalized therapy. Here we describe an implantable diagnostic device that senses the local in vivo environment. This device, which could be left behind during biopsy, uses a semi-permeable membrane to contain nanoparticle magnetic relaxation switches. A cell line secreting a model cancer biomarker produced ectopic tumors in mice. The transverse relaxation time (T2) of devices in tumor-bearing mice was 20 ± 10% lower than devices in control mice after 1 day by magnetic resonance imaging (p < 0.01). Short term applications for this device are numerous, including verification of successful tumor resection. This may represent the first continuous monitoring device for soluble cancer biomarkers in vivo.
KW - Cancer biomarker
KW - Human chorionic gonadotrophin
KW - In vivo sensor
KW - Magnetic nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=67349195523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349195523&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2009.04.010
DO - 10.1016/j.bios.2009.04.010
M3 - Article
C2 - 19442510
AN - SCOPUS:67349195523
SN - 0956-5663
VL - 24
SP - 3252
EP - 3257
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
IS - 11
ER -