Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice

Michael P. Horan, Ning Quan, Sukanya V. Subramanian, Arthur R. Strauch, Praveen K. Gajendrareddy, Phillip Marucha

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Previous research has shown that psychological stress delays wound closure by >25%. Gene expression of pro-inflammatory cytokines and the maturation of the epithelium were also impaired by stress (Mercado et al.). Wound contraction contributes to the speed of wound closure (Hunt and Hopf). In the current study, wound contraction was decreased by >45% (p 25% (p

Original languageEnglish (US)
Pages (from-to)207-216
Number of pages10
JournalBrain, Behavior, and Immunity
Volume19
Issue number3
DOIs
StatePublished - May 2005
Externally publishedYes

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Myofibroblasts
Wounds and Injuries
Psychological Stress
Epithelium
Cytokines
Gene Expression
Research

Keywords

  • Contraction
  • Myofibroblast
  • Stress
  • Wound Healing

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice. / Horan, Michael P.; Quan, Ning; Subramanian, Sukanya V.; Strauch, Arthur R.; Gajendrareddy, Praveen K.; Marucha, Phillip.

In: Brain, Behavior, and Immunity, Vol. 19, No. 3, 05.2005, p. 207-216.

Research output: Contribution to journalArticle

Horan, Michael P. ; Quan, Ning ; Subramanian, Sukanya V. ; Strauch, Arthur R. ; Gajendrareddy, Praveen K. ; Marucha, Phillip. / Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice. In: Brain, Behavior, and Immunity. 2005 ; Vol. 19, No. 3. pp. 207-216.
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