Impaired baroreflex gain during pregnancy in conscious rats

Role of brain insulin

Afaf S. Azar, Virginia Brooks

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pregnancy impairs baroreflex gain, but the mechanism is incompletely understood. To test the hypothesis that reductions in brain insulin contribute, we determined whether pregnant rats exhibit lower cerebrospinal fluid (CSF) insulin concentrations and whether intracerebroventricular infusion of insulin normalizes gain of baroreflex control of heart rate in conscious pregnant rats. CSF insulin was lower in pregnant (68±21 pg/mL) compared to virgin (169±25 pg/mL) rats (P

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalHypertension
Volume57
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Baroreflex
Insulin
Pregnancy
Brain
Cerebrospinal Fluid
Intraventricular Infusions
Heart Rate

Keywords

  • baroreceptor reflex sensitivity
  • cerebrospinal fluid insulin
  • heart rate
  • insulin resistance
  • pregnant

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Impaired baroreflex gain during pregnancy in conscious rats : Role of brain insulin. / Azar, Afaf S.; Brooks, Virginia.

In: Hypertension, Vol. 57, No. 2, 02.2011, p. 283-288.

Research output: Contribution to journalArticle

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