Impact of CD4+ Lymphocytes and HIV Infection on Anti-Müllerian Hormone Levels in a Large Cohort of HIV-infected and HIV-uninfected Women

Rebecca Scherzer, Peter Bacchetti, Geralyn Messerlian, Johanna Goderre, Pauline M. Maki, David Seifer, Kathryn Anastos, Roksana Karim, Ruth M. Greenblatt

12 Scopus citations


Problem: Effects of HIV infection on ovarian function and aging are unclear. Method of study: Anti-Müllerian Hormone (AMH) levels were analyzed in 2621 HIV-infected and 941 uninfected participants using left-censored longitudinal models. Results: Age-adjusted AMH levels were 16% lower in women with undetectable viraemia and 26% lower in detectable viraemia, relative to uninfected women. Current CD4 count associated with higher AMH in both HIV-infected and HIV-uninfected women. After controlling for current and nadir CD4, AMH was ~15% higher in HIV-infected relative to uninfected women, regardless of HIV viraemia. Gravidity, amenorrhea, and nadir total lymphocyte counts associated with higher AMH; hormonal contraceptive use and past weight loss associated with lower AMH. Conclusions: CD4 + lymphocyte counts were associated with AMH in both HIV-infected and uninfected women. After adjustment for CD4 counts and age, HIV infection was associated with higher AMH. CD4 T cells and cellular activation may influence ovarian granulosa cell function.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalAmerican Journal of Reproductive Immunology
Issue number3
Publication statusPublished - Mar 1 2015
Externally publishedYes



  • Anti-Müllerian hormone
  • CD4 lymphocytes
  • HIV
  • Menopause
  • Ovarian follicle

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

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