Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese zucker rats

Leslie J. Stein, Daniel M. Dorsa, Denis G. Askin, Dianne P. Figlewicz, Hitoshi Ikeda, Sandra P. Rarikmann, M. R.C. Greenwood, Daniel Porte, Stephen C. Woods

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Abstract

Immunoreactive insulin (IRI) concentrations were measured in plasma and cerebrospinal fluid (CSF) of four-month old genetically obese Zucker rats, their heterozygote lean littermates, and age-matched normalweight Wistar rats. Basal plasma IRI was 201 ± 35 uU/ml (X ± SEM) in the obese animals and was significantly elevated compared to both lean Zucker rats (18 ± 2.4 μg/ml, P<0.001) and Wistar rats (12 ± 2.4 μg/ml, P<0.001). The mean CSF IRI concentration of fasted obese Zucker rats was 1.59 ± 0.19 μg/ml; this was significantly higher than the CSF IRI level of either fasted Zucker lean rats (0.31 ± 0.08 μg/ml, P<0.001) or Wistar rats.

Original languageEnglish (US)
Pages (from-to)2299-2301
Number of pages3
JournalEndocrinology
Volume113
Issue number6
DOIs
StatePublished - Dec 1983

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ASJC Scopus subject areas

  • Endocrinology

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Stein, L. J., Dorsa, D. M., Askin, D. G., Figlewicz, D. P., Ikeda, H., Rarikmann, S. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1983). Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese zucker rats. Endocrinology, 113(6), 2299-2301. https://doi.org/10.1210/endo-113-6-2299