Immunopathogenesis: The role of mucosal and skin microbiota in SLE

Teri M. Greiling, Martin A. Kriegel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The human microbiota forms a life-long reciprocal relationship with the host influencing the innate and adaptive immune system. The pathogenesis of systemic lupus erythematosus (SLE) involves dysregulation of innate and adaptive immune mechanisms that normally function to defend against microbes, but instead turn against self-antigens. Loss of self-tolerance is one of the fundamental mechanisms of autoimmunity and the influence of the microbiota on this process is increasingly recognized. Loss of beneficial microbes or outgrowth of certain pathobionts driving innate or adaptive immune responses have recently been discovered in rheumatic diseases and will be reviewed in this chapter with a focus on SLE.

Original languageEnglish (US)
Title of host publicationLahita’s Systemic Lupus Erythematosus
PublisherElsevier
Pages117-130
Number of pages14
ISBN (Electronic)9780128205839
DOIs
StatePublished - Jan 1 2021
Externally publishedYes

Keywords

  • Antiphospholipid syndrome
  • Cross-reactivity

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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