Immunoneutralization of oxytocin attenuates stress-induced corticotropin secretion in the rat

Daniel M. Gibbs

doi:10.1016/0167-0115(85)90170-3

Immunoneutralization of oxytocin attenuates stress-induced corticotropin secretion in the rat

Daniel M. Gibbs

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Recent studies have demonstrated that oxytocin (OT) is released during certain stresses and that OT can potentiate the activity of CRF in vitro. To better define the role of OT during stress, the effect of injections of anti-OT antiserum on stress-induced corticotropin (ACTH) secretion was studied in vivo. A dose of antiserum which completely neutralized the increase in plasma OT levels during tail-hang stress caused a 59% decrease in plasma ACTH concentrations (P < 0.005). The data support a physiologic role for OT in the regulation of ACTH secretion.

Original language	English (US)
Pages (from-to)	273-277
Number of pages	5
Journal	Regulatory Peptides
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0167-0115(85)90170-3
State	Published - Nov 28 1985
Externally published	Yes

Keywords

ACTH
oxytocin
stress

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(85)90170-3

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title = "Immunoneutralization of oxytocin attenuates stress-induced corticotropin secretion in the rat",

abstract = "Recent studies have demonstrated that oxytocin (OT) is released during certain stresses and that OT can potentiate the activity of CRF in vitro. To better define the role of OT during stress, the effect of injections of anti-OT antiserum on stress-induced corticotropin (ACTH) secretion was studied in vivo. A dose of antiserum which completely neutralized the increase in plasma OT levels during tail-hang stress caused a 59% decrease in plasma ACTH concentrations (P < 0.005). The data support a physiologic role for OT in the regulation of ACTH secretion.",

keywords = "ACTH, oxytocin, stress",

author = "Gibbs, {Daniel M.}",

note = "Funding Information: This research was supported by a Mellon Foundation Faculty Scholar Award and by NIH grant AM-32517. I would like to thank Susan Simerson for skillful technical assistance.",

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AU - Gibbs, Daniel M.

N1 - Funding Information: This research was supported by a Mellon Foundation Faculty Scholar Award and by NIH grant AM-32517. I would like to thank Susan Simerson for skillful technical assistance.

PY - 1985/11/28

Y1 - 1985/11/28

N2 - Recent studies have demonstrated that oxytocin (OT) is released during certain stresses and that OT can potentiate the activity of CRF in vitro. To better define the role of OT during stress, the effect of injections of anti-OT antiserum on stress-induced corticotropin (ACTH) secretion was studied in vivo. A dose of antiserum which completely neutralized the increase in plasma OT levels during tail-hang stress caused a 59% decrease in plasma ACTH concentrations (P < 0.005). The data support a physiologic role for OT in the regulation of ACTH secretion.

AB - Recent studies have demonstrated that oxytocin (OT) is released during certain stresses and that OT can potentiate the activity of CRF in vitro. To better define the role of OT during stress, the effect of injections of anti-OT antiserum on stress-induced corticotropin (ACTH) secretion was studied in vivo. A dose of antiserum which completely neutralized the increase in plasma OT levels during tail-hang stress caused a 59% decrease in plasma ACTH concentrations (P < 0.005). The data support a physiologic role for OT in the regulation of ACTH secretion.

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KW - oxytocin

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JO - Regulatory Peptides

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Immunoneutralization of oxytocin attenuates stress-induced corticotropin secretion in the rat

Abstract

Keywords

ASJC Scopus subject areas

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