Immune response to ultraviolet-induced tumors: III. analysis of cloned lymphocyte populations exhibiting antitumor activity

Philip R. Streeter, G. William Fortner

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Previously, we hypothesized that natural killer lymphocytes could function as effector cells in the rejection of UV-induced tumors in tumor-immune animals. Immunization with progressor UV-tumor 2237 induced lymphocytes exhibiting natural cell-mediated cytotoxicity but failed to elicit tumor-specific cytolytic T lymphocytes. In the present investigation, T lymphocyte cloning technology provided a means of isolating homogeneous lymphocyte populations exhibiting CTL and NK activities. Clones with both CTL and NK activity were isolated from regressor-1316-immune mice, but NK-like clones only were isolated from progressor- 2237-immune mice. An evaluation of the in situ anti- UV-tumor action of a representative NK lymphocyte clone revealed that these cells could in fact prevent tumor outgrowth, supporting our hypothesis that these cells could function as effector cells in UV-tumor rejection responses in tumor-immune animals.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalTransplantation
Volume46
Issue number2
DOIs
StatePublished - Aug 1988

ASJC Scopus subject areas

  • Transplantation

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