Abstract
Previously, we hypothesized that natural killer lymphocytes could function as effector cells in the rejection of UV-induced tumors in tumor-immune animals. Immunization with progressor UV-tumor 2237 induced lymphocytes exhibiting natural cell-mediated cytotoxicity but failed to elicit tumor-specific cytolytic T lymphocytes. In the present investigation, T lymphocyte cloning technology provided a means of isolating homogeneous lymphocyte populations exhibiting CTL and NK activities. Clones with both CTL and NK activity were isolated from regressor-1316-immune mice, but NK-like clones only were isolated from progressor- 2237-immune mice. An evaluation of the in situ anti- UV-tumor action of a representative NK lymphocyte clone revealed that these cells could in fact prevent tumor outgrowth, supporting our hypothesis that these cells could function as effector cells in UV-tumor rejection responses in tumor-immune animals.
Original language | English (US) |
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Pages (from-to) | 256-260 |
Number of pages | 5 |
Journal | Transplantation |
Volume | 46 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Transplantation