Immune response to ultraviolet-induced tumors

III. analysis of cloned lymphocyte populations exhibiting antitumor activity

Philip Streeter, G. William Fortner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Previously, we hypothesized that natural killer lymphocytes could function as effector cells in the rejection of UV-induced tumors in tumor-immune animals. Immunization with progressor UV-tumor 2237 induced lymphocytes exhibiting natural cell-mediated cytotoxicity but failed to elicit tumor-specific cytolytic T lymphocytes. In the present investigation, T lymphocyte cloning technology provided a means of isolating homogeneous lymphocyte populations exhibiting CTL and NK activities. Clones with both CTL and NK activity were isolated from regressor-1316-immune mice, but NK-like clones only were isolated from progressor- 2237-immune mice. An evaluation of the in situ anti- UV-tumor action of a representative NK lymphocyte clone revealed that these cells could in fact prevent tumor outgrowth, supporting our hypothesis that these cells could function as effector cells in UV-tumor rejection responses in tumor-immune animals.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalTransplantation
Volume46
Issue number2
StatePublished - 1988
Externally publishedYes

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Lymphocytes
Population
Neoplasms
Clone Cells
T-Lymphocytes
Organism Cloning
Immunization
Technology

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Immune response to ultraviolet-induced tumors : III. analysis of cloned lymphocyte populations exhibiting antitumor activity. / Streeter, Philip; Fortner, G. William.

In: Transplantation, Vol. 46, No. 2, 1988, p. 256-260.

Research output: Contribution to journalArticle

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