Immune cells as anti-cancer therapeutic targets and tools

Magnus Johansson, Tingting Tan, Karin E. De Visser, Lisa M. Coussens

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Chronic inflammation is a contributing factor to overall cancer risk as well as cancer promotion and progression; however, pathways regulating onset of cancer-promoting inflammatory responses are still poorly understood. Clinical data suggest that deficient anti-tumor cell-mediated immunity, in combination with enhanced pro-tumor humoral and/or innate immunity (inflammation), are significant factors influencing malignant outcome. Here, we discuss therapeutic implications from clinical data and experimental studies using de novo immune-competent mouse models of cancer development that together are revealing molecular and cellular mechanisms underlying interactions between immune cells and evolving neoplastic cells that regulate cancer outcome. Understanding the functionally significant links between adaptive and innate immunity that regulate cancer development will open new therapeutic opportunities to manipulate aspects of immunobiology and minimize lethal effects of cancer development.

Original languageEnglish (US)
Pages (from-to)918-926
Number of pages9
JournalJournal of cellular biochemistry
Volume101
Issue number4
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Keywords

  • Adative
  • Cancer
  • Immune cells
  • Inflammation
  • Innate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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