Immobilization of Actively Thromboresistant Assemblies on Sterile Blood-Contacting Surfaces

Zheng Qu, Venkat Krishnamurthy, Carolyn A. Haller, Brent M. Dorr, Ulla M. Marzec, Sawan Hurst, Monica T. Hinds, Stephen R. Hanson, David R. Liu, Elliot L. Chaikof

Research output: Contribution to journalLetter

23 Scopus citations

Abstract

Rapid one-step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point-of-care scheme is demonstrated herein to site-specifically immobilize azido-thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin-coated grafts in a primate model of acute graft thrombosis.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalAdvanced Healthcare Materials
Volume3
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Antifouling
  • Biocompatible materials
  • Biomedical applications
  • Thrombomodulin
  • Thrombosis

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Immobilization of Actively Thromboresistant Assemblies on Sterile Blood-Contacting Surfaces'. Together they form a unique fingerprint.

  • Cite this

    Qu, Z., Krishnamurthy, V., Haller, C. A., Dorr, B. M., Marzec, U. M., Hurst, S., Hinds, M. T., Hanson, S. R., Liu, D. R., & Chaikof, E. L. (2014). Immobilization of Actively Thromboresistant Assemblies on Sterile Blood-Contacting Surfaces. Advanced Healthcare Materials, 3(1), 30-35. https://doi.org/10.1002/adhm.201300110