Imaging retinal structures at cellular-level resolution by visible-light optical coherence tomography

Shaohua Pi, Tristan T. Hormel, Xiang Wei, William Cepurna, John C. Morrison, Yali Jia

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In vivo high-resolution images are the most direct way to understand retinal function and diseases. Here we report the use of visible-light optical coherence tomography with volumetric registration and averaging to achieve cellular-level retinal structural imaging in a rat eye, covering the entire depth of the retina. Vitreous fibers, nerve fiber bundles, and vasculature were clearly revealed, as well as at least three laminar sublayers in the inner plexiform layer. We also successfully visualized ganglion cell somas in the ganglion cell layer, cells in the inner nuclear layer, and photoreceptors in the outer nuclear layer and ellipsoid zone. This technique provides, to the best of our knowledge, a new means to visualize the retina in vivo at a cellular resolution and may enable detection or discovery of cellular neuronal biomarkers to help better diagnose ocular disease.

Original languageEnglish (US)
Pages (from-to)2107-2110
Number of pages4
JournalOptics Letters
Volume45
Issue number7
DOIs
StatePublished - Apr 1 2020

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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