Imaging brain tumors with ferumoxtran-10, a nanoparticle magnetic resonance contrast agent

Tulio P. Murillo, Chloe Sandquist, Paula M. Jacobs, Gary Nesbit, Sandor Manninger, Edward Neuwelt

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Ultrasmall superparamagnetic particles of iron oxide are magnetic resonance contrast agents that are gaining use in the CNS. These agents accumulate in phagocytic cells such as reactive astrocytes and macrophages. Aim: We aimed to describe the use of ferumoxtran-10, an ultrasmall superparamagnetic particle of iron oxide, in brain tumor imaging and detail the results in a series of 55 patients with intracranial tumors. Results: In 19 out of 34 glial tumors, ferumoxtran-10 enhanced as much as (n = 9) or more than gadolinium (n = 10). In the nonglial tumors group, seven out of 22 tumors enhanced as much as (n = 2) or more than gadolinium (n = 5). Conclusion: Ferumoxtran-10-enhanced magnetic resonance can add information to gadolinium-enhanced magnetic resonance, especially in identifying the inflammatory component and blood-brain barrier compromize involved in infiltrating malignant brain tumors.

Original languageEnglish (US)
Pages (from-to)871-882
Number of pages12
JournalTherapy
Volume2
Issue number6
DOIs
StatePublished - Nov 2005

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Brain Neoplasms
Nanoparticles
Contrast Media
Magnetic Resonance Spectroscopy
Gadolinium
Neoplasms
Phagocytes
Blood-Brain Barrier
Neuroimaging
Neuroglia
Astrocytes
Macrophages
ferumoxtran-10

Keywords

  • Ferumoxtran-10
  • Glioma
  • Inflammation
  • Magnetic resonance contrast agents
  • Metastatic brain tumors
  • Ultrasmall superparamagnetic iron oxide

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Imaging brain tumors with ferumoxtran-10, a nanoparticle magnetic resonance contrast agent. / Murillo, Tulio P.; Sandquist, Chloe; Jacobs, Paula M.; Nesbit, Gary; Manninger, Sandor; Neuwelt, Edward.

In: Therapy, Vol. 2, No. 6, 11.2005, p. 871-882.

Research output: Contribution to journalArticle

Murillo, TP, Sandquist, C, Jacobs, PM, Nesbit, G, Manninger, S & Neuwelt, E 2005, 'Imaging brain tumors with ferumoxtran-10, a nanoparticle magnetic resonance contrast agent', Therapy, vol. 2, no. 6, pp. 871-882. https://doi.org/10.1586/14750708.2.6.871
Murillo, Tulio P. ; Sandquist, Chloe ; Jacobs, Paula M. ; Nesbit, Gary ; Manninger, Sandor ; Neuwelt, Edward. / Imaging brain tumors with ferumoxtran-10, a nanoparticle magnetic resonance contrast agent. In: Therapy. 2005 ; Vol. 2, No. 6. pp. 871-882.
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