Image contrast in fluorescence and magnetic resonance images for glioblastoma detection

Kimberley S. Samkoe, Summer Gibbs, Harold H. Yang, S. Khan Hekmatyar, P. Jack Hoopes, Julia A. O'Hara, Risto A. Kauppinen, Brian W. Pogue

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A diffusely infiltrative human glioma cell line (U251-GFP) has been developed and used as a model for the tumor growth outside of MR image detectable tumor boundary. The aminolevulinic acid-protoporphyrin IX (ALA-PpIX) fluorescence system has shown great strides for fluorescence guided surgical resection, but often fluorescence is observed outside of the MR image detectable tumor margin. Here we compare the use of ALA-PpIX fluorescence with that of standard gadolinium enhanced MR imaging as well as T2 and diffusion imaging to determine whether there is a correlation between fluorescence and MR imaging. We found that PpIX fluorescence, T1WCD and Absolute T2 images have the highest contrast difference from controls and are likely candidates for highly infiltrative tumor detection.

Original languageEnglish (US)
Title of host publicationMultimodal Biomedical Imaging VI
Volume7892
DOIs
StatePublished - 2011
Externally publishedYes
EventMultimodal Biomedical Imaging VI - San Francisco, CA, United States
Duration: Jan 22 2011Jan 23 2011

Other

OtherMultimodal Biomedical Imaging VI
CountryUnited States
CitySan Francisco, CA
Period1/22/111/23/11

Fingerprint

image contrast
resonance fluorescence
Magnetic resonance
Glioblastoma
magnetic resonance
Magnetic Resonance Spectroscopy
Fluorescence
fluorescence
Tumors
tumors
Aminolevulinic Acid
Neoplasms
Imaging techniques
Optical Imaging
Gadolinium
acids
Acids
Glioma
gadolinium
cultured cells

Keywords

  • fluorescence-guided resection
  • glioblastoma
  • image contrast
  • magnetic resonance imaging (MRI)
  • protoporphyrin IX (PpIX)
  • U251-GFP

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Samkoe, K. S., Gibbs, S., Yang, H. H., Hekmatyar, S. K., Hoopes, P. J., O'Hara, J. A., ... Pogue, B. W. (2011). Image contrast in fluorescence and magnetic resonance images for glioblastoma detection. In Multimodal Biomedical Imaging VI (Vol. 7892). [78920O] https://doi.org/10.1117/12.875425

Image contrast in fluorescence and magnetic resonance images for glioblastoma detection. / Samkoe, Kimberley S.; Gibbs, Summer; Yang, Harold H.; Hekmatyar, S. Khan; Hoopes, P. Jack; O'Hara, Julia A.; Kauppinen, Risto A.; Pogue, Brian W.

Multimodal Biomedical Imaging VI. Vol. 7892 2011. 78920O.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Samkoe, KS, Gibbs, S, Yang, HH, Hekmatyar, SK, Hoopes, PJ, O'Hara, JA, Kauppinen, RA & Pogue, BW 2011, Image contrast in fluorescence and magnetic resonance images for glioblastoma detection. in Multimodal Biomedical Imaging VI. vol. 7892, 78920O, Multimodal Biomedical Imaging VI, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.875425
Samkoe KS, Gibbs S, Yang HH, Hekmatyar SK, Hoopes PJ, O'Hara JA et al. Image contrast in fluorescence and magnetic resonance images for glioblastoma detection. In Multimodal Biomedical Imaging VI. Vol. 7892. 2011. 78920O https://doi.org/10.1117/12.875425
Samkoe, Kimberley S. ; Gibbs, Summer ; Yang, Harold H. ; Hekmatyar, S. Khan ; Hoopes, P. Jack ; O'Hara, Julia A. ; Kauppinen, Risto A. ; Pogue, Brian W. / Image contrast in fluorescence and magnetic resonance images for glioblastoma detection. Multimodal Biomedical Imaging VI. Vol. 7892 2011.
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