Image contrast in fluorescence and magnetic resonance images for glioblastoma detection

Kimberley S. Samkoe, Summer L. Gibbs-Strauss, Harold H. Yang, S. Khan Hekmatyar, P. Jack Hoopes, Julia A. O'Hara, Risto A. Kauppinen, Brian W. Pogue

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A diffusely infiltrative human glioma cell line (U251-GFP) has been developed and used as a model for the tumor growth outside of MR image detectable tumor boundary. The aminolevulinic acid-protoporphyrin IX (ALA-PpIX) fluorescence system has shown great strides for fluorescence guided surgical resection, but often fluorescence is observed outside of the MR image detectable tumor margin. Here we compare the use of ALA-PpIX fluorescence with that of standard gadolinium enhanced MR imaging as well as T2 and diffusion imaging to determine whether there is a correlation between fluorescence and MR imaging. We found that PpIX fluorescence, T1WCD and Absolute T2 images have the highest contrast difference from controls and are likely candidates for highly infiltrative tumor detection.

Original languageEnglish (US)
Title of host publicationMultimodal Biomedical Imaging VI
StatePublished - 2011
Externally publishedYes
EventMultimodal Biomedical Imaging VI - San Francisco, CA, United States
Duration: Jan 22 2011Jan 23 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMultimodal Biomedical Imaging VI
Country/TerritoryUnited States
CitySan Francisco, CA


  • U251-GFP
  • fluorescence-guided resection
  • glioblastoma
  • image contrast
  • magnetic resonance imaging (MRI)
  • protoporphyrin IX (PpIX)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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