IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

Jun Zhang, Gil Benedek, Sheetal Bodhankar, Andrew Lapato, Arthur A. Vandenbark, Halina Offner

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Women with multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17β-estradiol)-mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that the transfer of IL-10+ B cells into E2-treated PD-L1-/- mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1-/- mice. Hence, co-administration of IL-10+ B cells and E2 might have a powerful therapeutic potential for treatment of EAE.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalJournal of Neuroimmunology
Volume285
DOIs
StatePublished - Jan 1 2015

Keywords

  • EAE
  • Estrogen
  • IL-10
  • PD-L1
  • PD-L2
  • Regulatory B cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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