Abstract
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKα in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.
Original language | English (US) |
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Pages (from-to) | 25-26 |
Number of pages | 2 |
Journal | Cell |
Volume | 129 |
Issue number | 1 |
DOIs | |
State | Published - Apr 6 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology