IKKα at the Crossroads of Inflammation and Metastasis

Nesrine I. Affara, Lisa M. Coussens

Research output: Contribution to journalShort surveypeer-review

45 Scopus citations

Abstract

The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKα in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.

Original languageEnglish (US)
Pages (from-to)25-26
Number of pages2
JournalCell
Volume129
Issue number1
DOIs
StatePublished - Apr 6 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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