IKKα at the Crossroads of Inflammation and Metastasis

Nesrine I. Affara, Lisa Coussens

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKα in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.

Original languageEnglish (US)
Pages (from-to)25-26
Number of pages2
JournalCell
Volume129
Issue number1
DOIs
StatePublished - Apr 6 2007
Externally publishedYes

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Tumors
Neoplasm Metastasis
Inflammation
Epithelial Cells
Cells
Cellular Microenvironment
Neoplasms
Chemical activation
SERPIN-B5

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

IKKα at the Crossroads of Inflammation and Metastasis. / Affara, Nesrine I.; Coussens, Lisa.

In: Cell, Vol. 129, No. 1, 06.04.2007, p. 25-26.

Research output: Contribution to journalArticle

Affara, Nesrine I. ; Coussens, Lisa. / IKKα at the Crossroads of Inflammation and Metastasis. In: Cell. 2007 ; Vol. 129, No. 1. pp. 25-26.
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