IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons

Kang Wang, Pedro Mateos-Aparicio, Christoph Hönigsperger, Vijeta Raghuram, Wendy Wu, Margreet C. Ridder, Pankaj Sah, James Maylie, Johan F. Storm, John Adelman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In pyramidal neurons such as hippocampal area CA1 and basolateral amygdala, a slow afterhyperpolarization (sAHP) follows a burst of action potentials, which is a powerful regulator of neuronal excitability. The sAHP amplitude increases with aging and may underlie age related memory decline. The sAHP is due to a Ca2+-dependent, voltage-independent K+ conductance, the molecular identity of which has remained elusive until a recent report suggested the Ca2+-activated K+ channel, IK1 (KCNN4) as the sAHP channel in CA1 pyramidal neurons. The signature pharmacology of IK1, blockade by TRAM-34, was reported for the sAHP and underlying current. We have examined the sAHP and find no evidence that TRAM-34 affects either the current underling the sAHP or excitability of CA1 or basolateral amygdala pyramidal neurons. In addition, CA1 pyramidal neurons from IK1 null mice exhibit a characteristic sAHP current. Our results indicate that IK1 channels do not mediate the sAHP in pyramidal neurons.

Original languageEnglish (US)
Article numbere11206
JournaleLife
Volume5
Issue numberJANUARY2016
DOIs
StatePublished - Jan 14 2016

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Pyramidal Cells
Neurons
Calcium-Activated Potassium Channels
Action Potentials
Aging of materials
Pharmacology
Data storage equipment
Electric potential
TRAM 34
Basolateral Nuclear Complex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Wang, K., Mateos-Aparicio, P., Hönigsperger, C., Raghuram, V., Wu, W., Ridder, M. C., ... Adelman, J. (2016). IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons. eLife, 5(JANUARY2016), [e11206]. https://doi.org/10.7554/eLife.11206

IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons. / Wang, Kang; Mateos-Aparicio, Pedro; Hönigsperger, Christoph; Raghuram, Vijeta; Wu, Wendy; Ridder, Margreet C.; Sah, Pankaj; Maylie, James; Storm, Johan F.; Adelman, John.

In: eLife, Vol. 5, No. JANUARY2016, e11206, 14.01.2016.

Research output: Contribution to journalArticle

Wang, K, Mateos-Aparicio, P, Hönigsperger, C, Raghuram, V, Wu, W, Ridder, MC, Sah, P, Maylie, J, Storm, JF & Adelman, J 2016, 'IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons', eLife, vol. 5, no. JANUARY2016, e11206. https://doi.org/10.7554/eLife.11206
Wang K, Mateos-Aparicio P, Hönigsperger C, Raghuram V, Wu W, Ridder MC et al. IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons. eLife. 2016 Jan 14;5(JANUARY2016). e11206. https://doi.org/10.7554/eLife.11206
Wang, Kang ; Mateos-Aparicio, Pedro ; Hönigsperger, Christoph ; Raghuram, Vijeta ; Wu, Wendy ; Ridder, Margreet C. ; Sah, Pankaj ; Maylie, James ; Storm, Johan F. ; Adelman, John. / IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons. In: eLife. 2016 ; Vol. 5, No. JANUARY2016.
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