Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families

L. Almasy, S. B. Bressman, D. Raymond, P. L. Kramer, P. E. Greene, G. A. Heiman, B. Ford, J. Yount, D. De Leon, S. Chouinard, R. Saunders-Pullman, M. F. Brin, R. P. Kapoor, A. C. Jones, H. Shen, S. Fahn, N. J. Risch, T. G. Nygaard

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Abstract

The DYT1 locus on chromosome 9q34 is responsible for most childhood limb-onset idiopathic torsion dystonia (ITD). Linkage to DYT1 has been excluded in families with adult-onset, and predominantly cranial-cervical, ITD. We mapped a locus (DYT6) associated with prominent cranial-cervical ITD in two large Mennonite families to chromosome 8. An identical haplotype spanning 40-cM segregates with ITD in these families, suggesting a shared mutation from the recent past.

Original languageEnglish (US)
Pages (from-to)670-673
Number of pages4
JournalAnnals of Neurology
Volume42
Issue number4
DOIs
StatePublished - Oct 1997

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Dystonia Musculorum Deformans
Chromosomes, Human, Pair 8
Haplotypes
Extremities
Chromosomes
Mutation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Almasy, L., Bressman, S. B., Raymond, D., Kramer, P. L., Greene, P. E., Heiman, G. A., ... Nygaard, T. G. (1997). Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families. Annals of Neurology, 42(4), 670-673. https://doi.org/10.1002/ana.410420421

Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families. / Almasy, L.; Bressman, S. B.; Raymond, D.; Kramer, P. L.; Greene, P. E.; Heiman, G. A.; Ford, B.; Yount, J.; De Leon, D.; Chouinard, S.; Saunders-Pullman, R.; Brin, M. F.; Kapoor, R. P.; Jones, A. C.; Shen, H.; Fahn, S.; Risch, N. J.; Nygaard, T. G.

In: Annals of Neurology, Vol. 42, No. 4, 10.1997, p. 670-673.

Research output: Contribution to journalArticle

Almasy, L, Bressman, SB, Raymond, D, Kramer, PL, Greene, PE, Heiman, GA, Ford, B, Yount, J, De Leon, D, Chouinard, S, Saunders-Pullman, R, Brin, MF, Kapoor, RP, Jones, AC, Shen, H, Fahn, S, Risch, NJ & Nygaard, TG 1997, 'Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families', Annals of Neurology, vol. 42, no. 4, pp. 670-673. https://doi.org/10.1002/ana.410420421
Almasy L, Bressman SB, Raymond D, Kramer PL, Greene PE, Heiman GA et al. Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families. Annals of Neurology. 1997 Oct;42(4):670-673. https://doi.org/10.1002/ana.410420421
Almasy, L. ; Bressman, S. B. ; Raymond, D. ; Kramer, P. L. ; Greene, P. E. ; Heiman, G. A. ; Ford, B. ; Yount, J. ; De Leon, D. ; Chouinard, S. ; Saunders-Pullman, R. ; Brin, M. F. ; Kapoor, R. P. ; Jones, A. C. ; Shen, H. ; Fahn, S. ; Risch, N. J. ; Nygaard, T. G. / Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families. In: Annals of Neurology. 1997 ; Vol. 42, No. 4. pp. 670-673.
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