@article{b57da87b2cb146cb81e3168b02fde93b,
title = "Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321",
abstract = "ARST1321, a trial of patients with advanced soft tissue sarcoma, was the first National Clinical Trials Network study codeveloped by pediatric and adult consortia with two treatment cohorts. We report on the findings of a survey to identify barriers to enrolling adolescent and young adult patients (15-39 years) onto the nonchemotherapy arm. The survey response rate was 31% with a 70% completion rate. Common identified reasons for low accrual in order of decreasing frequency included insufficient funding, lack of study awareness or interest, competing trials, toxicity concerns, philosophical differences in the therapy backbone, and regulatory and infrastructure barriers. Clinical Trials.gov ID: NCT02180867.",
keywords = "NCTN, clinical trials, cooperative groups, enrollment barriers, survey",
author = "Viswatej Avutu and Weiss, {Aaron R.} and Reed, {Damon R.} and Ahmed, {Safia K.} and Allen-Rhoades, {Wendy A.} and Chen, {Yen Lin E.} and Davis, {Lara E.} and Eaton, {Bree R.} and Hawkins, {Douglas S.} and Indelicato, {Danny J.} and Patel, {Shreyaskumar R.} and Randall, {R. Lor} and Reinke, {Denise K.} and Riedel, {Richard F.} and Scharschmidt, {Thomas J.} and Thornton, {Katherine A.} and Dian Wang and Janeway, {Katherine A.} and Kopp, {Lisa M.}",
note = "Funding Information: ARST1321 was funded by National Clinical Trials Network Operations Center Grant U10CA180886, National Clinical Trials Network Statistics & Data Center Grant U10CA180899, the National Cancer Institute IROC Operations Grant CA180803, St. Baldrick's Foundation, and Seattle Children's Foundation, from Kat's Crew Guild through the Sarcoma Research Fund Funding Information: ARST1321 was funded by National Clinical Trials Network Operations Center Grant U10CA180886, National Clinical Trials Network Statistics & Data Center Grant U10CA180899, the National Cancer Institute IROC Operations Grant CA180803, St. Baldrick{\textquoteright}s Foundation, and Seattle Children{\textquoteright}s Foundation, from Kat{\textquoteright}s Crew Guild through the Sarcoma Research Fund. Publisher Copyright: {\textcopyright} Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.",
year = "2022",
month = jun,
day = "1",
doi = "10.1089/jayao.2021.0103",
language = "English (US)",
volume = "11",
pages = "328--332",
journal = "Journal of Adolescent and Young Adult Oncology",
issn = "2156-5333",
publisher = "Mary Ann Liebert Inc.",
number = "3",
}