Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Curtis R. Chong, David Z. Qian, Fan Pan, Yongfeng Wei, Roberto Pili, David J. Sullivan, Jun O. Liu

    Research output: Contribution to journalArticle

    78 Scopus citations

    Abstract

    To rapidly discover clinically useful angiogenesis inhibitors, we created and screened a library of existing drugs for inhibition of endothelial cell proliferation. Mycophenolic acid (MPA), an immunosuppressive drug, was found to potently inhibit endothelial cell proliferation in vitro and block tumor-induced angiogenesis in vivo. Using RNA interference, we found that knockdown of one of the two known isoforms of inosine monophosphate dehydrogenase (IMPDH-1) is sufficient to cause endothelial cell cycle arrest.

    Original languageEnglish (US)
    Pages (from-to)2677-2680
    Number of pages4
    JournalJournal of Medicinal Chemistry
    Volume49
    Issue number9
    DOIs
    StatePublished - May 4 2006

    ASJC Scopus subject areas

    • Molecular Medicine
    • Drug Discovery

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