Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11

Kou Kou, Payton L. James, David R. Clemmons, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Peter Rotwein

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group.

Original languageEnglish (US)
Pages (from-to)653-655
Number of pages3
JournalGenomics
Volume21
Issue number3
DOIs
StatePublished - Jun 1994

ASJC Scopus subject areas

  • Genetics

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    Kou, K., James, P. L., Clemmons, D. R., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Rotwein, P. (1994). Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11. Genomics, 21(3), 653-655. https://doi.org/10.1006/geno.1994.1329