Identification of Two Clusters of Mouse Insulin-like Growth Factor Binding Protein Genes on Chromosomes 1 and 11

Kou Kou, Payton L. James, David R. Clemmons, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Peter Rotwein

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group.

Original languageEnglish (US)
Pages (from-to)653-655
Number of pages3
JournalGenomics
Volume21
Issue number3
DOIs
StatePublished - Jun 1994
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Proteins
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 1
Tail
Genes
Insulin-Like Growth Factor II
Chromosome Mapping
Human Chromosomes
Human Genome
Insulin-Like Growth Factor I
Organism Cloning
Chromosomes
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Kou, K., James, P. L., Clemmons, D. R., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Rotwein, P. (1994). Identification of Two Clusters of Mouse Insulin-like Growth Factor Binding Protein Genes on Chromosomes 1 and 11. Genomics, 21(3), 653-655. https://doi.org/10.1006/geno.1994.1329

Identification of Two Clusters of Mouse Insulin-like Growth Factor Binding Protein Genes on Chromosomes 1 and 11. / Kou, Kou; James, Payton L.; Clemmons, David R.; Copeland, Neal G.; Gilbert, Debra J.; Jenkins, Nancy A.; Rotwein, Peter.

In: Genomics, Vol. 21, No. 3, 06.1994, p. 653-655.

Research output: Contribution to journalArticle

Kou, K, James, PL, Clemmons, DR, Copeland, NG, Gilbert, DJ, Jenkins, NA & Rotwein, P 1994, 'Identification of Two Clusters of Mouse Insulin-like Growth Factor Binding Protein Genes on Chromosomes 1 and 11', Genomics, vol. 21, no. 3, pp. 653-655. https://doi.org/10.1006/geno.1994.1329
Kou, Kou ; James, Payton L. ; Clemmons, David R. ; Copeland, Neal G. ; Gilbert, Debra J. ; Jenkins, Nancy A. ; Rotwein, Peter. / Identification of Two Clusters of Mouse Insulin-like Growth Factor Binding Protein Genes on Chromosomes 1 and 11. In: Genomics. 1994 ; Vol. 21, No. 3. pp. 653-655.
@article{e13edbee7981475e98ea95012519a940,
title = "Identification of Two Clusters of Mouse Insulin-like Growth Factor Binding Protein Genes on Chromosomes 1 and 11",
abstract = "The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group.",
author = "Kou Kou and James, {Payton L.} and Clemmons, {David R.} and Copeland, {Neal G.} and Gilbert, {Debra J.} and Jenkins, {Nancy A.} and Peter Rotwein",
year = "1994",
month = "6",
doi = "10.1006/geno.1994.1329",
language = "English (US)",
volume = "21",
pages = "653--655",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Identification of Two Clusters of Mouse Insulin-like Growth Factor Binding Protein Genes on Chromosomes 1 and 11

AU - Kou, Kou

AU - James, Payton L.

AU - Clemmons, David R.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Rotwein, Peter

PY - 1994/6

Y1 - 1994/6

N2 - The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group.

AB - The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group.

UR - http://www.scopus.com/inward/record.url?scp=0028322140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028322140&partnerID=8YFLogxK

U2 - 10.1006/geno.1994.1329

DO - 10.1006/geno.1994.1329

M3 - Article

C2 - 7525452

AN - SCOPUS:0028322140

VL - 21

SP - 653

EP - 655

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 3

ER -