Identification of sodium channel subtypes induced in cultured retinal pigment epithelium cells

Heather Dawes, Gail Mandel, Gary Matthews

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Recent electrophysiological experiments have shown that retinal pigment epithelium (RPE) cells begin to produce neuronal-type voltage-dependent sodium currents when placed in dissociated cell culture. In this study, the sodium channel types induced in cultured rat RPE cells were identified. Sodium channel mRNAs encoding two distinct alpha subunits were detected in the cultured RPE cells, brain type II/IIA, and a novel rat mRNA which we have termed RET1. These two sodium channel types may correspond to the TTX-sensitive and TTX-insensitive components of sodium current reported previously in cultured rat RPE cells.

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalVisual neuroscience
Volume12
Issue number5
DOIs
StatePublished - Jan 1 1995

Keywords

  • Molecular biology
  • Retina
  • Retinal pigment epithelium
  • Sodium channel

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems

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