Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines

Paula J. Bice, Tatiana Foroud, Lucinda G. Carr, Lili Zhang, Lixiang Liu, Nicholas J. Grahame, Lawrence Lumeng, Ting Kai Li, John Belknap

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The High- and Low-Alcohol Preferring (HAP1/LAP1 and HAP2/LAP2) mouse lines were developed by selective breeding for differences in alcohol preference. They represent the only extant selectively bred mouse lines developed for this alcohol phenotype. Therefore, they provide a unique resource for QTL detection and mapping. Importantly, neither of the replicate lines is inbred and therefore, novel study designs can be employed to detect loci contributing to alcohol preference. Two independent studies, with very different approaches, were conducted in the HAP and LAP replicate lines. In Study 7, microsatellite markers were genotyped in the replicate HAP1/LAP1 and HAP2/LAP2 mice in QTL regions nominated by other mouse RI and F2 studies in order to detect divergence of allele frequencies in the two oppositely selected lines. Significant differences in allele frequencies were observed in the HAP1/LAP1 mice with markers on chromosome 9 (p

Original languageEnglish (US)
Pages (from-to)248-260
Number of pages13
JournalBehavior Genetics
Volume36
Issue number2
DOIs
StatePublished - Mar 2006

Fingerprint

alcohol
quantitative trait loci
alcohols
Alcohols
mice
Gene Frequency
gene frequency
allele
selective breeding
Chromosomes, Human, Pair 9
selection methods
Microsatellite Repeats
phenotype
chromosome
experimental design
divergence
microsatellite repeats
chromosomes
breeds
Phenotype

Keywords

  • Alcohol preference
  • HAP and LAP mice
  • QTL
  • Selective breeding

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines. / Bice, Paula J.; Foroud, Tatiana; Carr, Lucinda G.; Zhang, Lili; Liu, Lixiang; Grahame, Nicholas J.; Lumeng, Lawrence; Li, Ting Kai; Belknap, John.

In: Behavior Genetics, Vol. 36, No. 2, 03.2006, p. 248-260.

Research output: Contribution to journalArticle

Bice, PJ, Foroud, T, Carr, LG, Zhang, L, Liu, L, Grahame, NJ, Lumeng, L, Li, TK & Belknap, J 2006, 'Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines', Behavior Genetics, vol. 36, no. 2, pp. 248-260. https://doi.org/10.1007/s10519-005-9019-6
Bice, Paula J. ; Foroud, Tatiana ; Carr, Lucinda G. ; Zhang, Lili ; Liu, Lixiang ; Grahame, Nicholas J. ; Lumeng, Lawrence ; Li, Ting Kai ; Belknap, John. / Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines. In: Behavior Genetics. 2006 ; Vol. 36, No. 2. pp. 248-260.
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