Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41

C. A. Smibert; D. C. Johnson; J. R. Smiley

doi:10.1099/0022-1317-73-2-467

Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41

C. A. Smibert, D. C. Johnson, J. R. Smiley

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.

Original language	English (US)
Pages (from-to)	467-470
Number of pages	4
Journal	Journal of General Virology
Volume	73
Issue number	2
DOIs	https://doi.org/10.1099/0022-1317-73-2-467
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Virology

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10.1099/0022-1317-73-2-467

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abstract = "The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.",

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Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41

Abstract

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