Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41

C. A. Smibert, David Johnson, J. R. Smiley

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Abstract

The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.

Original languageEnglish (US)
Pages (from-to)467-470
Number of pages4
JournalJournal of General Virology
Volume73
Issue number2
Publication statusPublished - 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Virology

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