@article{b4b4b9d39eec45229811e1dcacfa6242,
title = "ICC-dementia (International Centenarian Consortium - dementia): An international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups",
abstract = "Background: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary aim is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. Methods: Studies focusing on individuals aged ≥95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. Discussion: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments.",
keywords = "Centenarians, Dementia, Incidence, International, Prevalence, Risk factors",
author = "Henry Brodaty and Claudia Woolf and Stacy Andersen and Nir Barzilai and Carol Brayne and Cheung, {Karen Siu Lan} and Corrada, {Maria M.} and Crawford, {John D.} and Catriona Daly and Yasuyuki Gondo and Bo Hagberg and Nobuyoshi Hirose and Henne Holstege and Claudia Kawas and Jeffrey Kaye and Kochan, {Nicole A.} and Lau, {Bobo Hi Po} and Ugo Lucca and Gabriella Marcon and Peter Martin and Poon, {Leonard W.} and Robyn Richmond and Robine, {Jean Marie} and Ingmar Skoog and Slavin, {Melissa J.} and Jan Szewieczek and Mauro Tettamanti and Jos{\'e} Vi{\~n}a and Thomas Perls and Sachdev, {Perminder S.}",
note = "Funding Information: The Sydney Centenarian Study is supported by the Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, University of New South Wales, Sydney, Australia. This study was supported by the National Health & Medical Research Council of Australia (project grant ID 630593 and program grant ID 568969; PS as principal investigator) The Oregon Brain Aging Study is supported in part by grants from the US Department of Veterans Affairs and the US National Institutes of Health (NIH), National Institute on Aging (P30 AG08017). The Polish Centenarian Study is funded by the Medical University of Silesia, Katowice, Poland and by the National Science Centre, Poland (Grant N 404 535439) from the budget for science during the years 2010-2014. The Georgia Centenarian Study is supported by the NIH (Grant PO1 AG17553-01A1; LWP as principal investigator). The Gothenburg 95+ Study was funded by the Swedish Research Council, Swedish Research Council for Health, Working Life and Welfare, and the Alzheimer's Association. The 100-plus Study is funded by Alzheimer- Nederland, Dioraphte and various private donations. The Monzino 80-plus Study is supported by a research grant from the Italo Monzino Foundation, Milano, Italy. The Tokyo Centenarian Study is supported by a grant from the Japanese Ministry of Health, Labour and Welfare. The Cognitive Function and Ageing study was funded by major awards from the Medical Research Council: Research Grant [G9901400] and the UK Department of Health. The funding bodies played no role in the formulation of the design, methods, subject recruitment, data collection, analysis, or preparation of this manuscript. Publisher Copyright: {\textcopyright} 2016 Brodaty et al.",
year = "2016",
month = apr,
day = "21",
doi = "10.1186/s12883-016-0569-4",
language = "English (US)",
volume = "16",
journal = "BMC Neurology",
issn = "1471-2377",
publisher = "BioMed Central",
number = "1",
}