Abstract
Background: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary aim is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. Methods: Studies focusing on individuals aged ≥95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. Discussion: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments.
| Original language | English (US) |
|---|---|
| Article number | 52 |
| Journal | BMC Neurology |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 21 2016 |
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Keywords
- Centenarians
- Dementia
- Incidence
- International
- Prevalence
- Risk factors
ASJC Scopus subject areas
- Clinical Neurology
Cite this
ICC-dementia (International Centenarian Consortium - dementia) : An international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. / Brodaty, Henry; Woolf, Claudia; Andersen, Stacy; Barzilai, Nir; Brayne, Carol; Cheung, Karen Siu Lan; Corrada, Maria M.; Crawford, John D.; Daly, Catriona; Gondo, Yasuyuki; Hagberg, Bo; Hirose, Nobuyoshi; Holstege, Henne; Kawas, Claudia; Kaye, Jeffrey; Kochan, Nicole A.; Lau, Bobo Hi Po; Lucca, Ugo; Marcon, Gabriella; Martin, Peter; Poon, Leonard W.; Richmond, Robyn; Robine, Jean Marie; Skoog, Ingmar; Slavin, Melissa J.; Szewieczek, Jan; Tettamanti, Mauro; Viña, José; Perls, Thomas; Sachdev, Perminder S.
In: BMC Neurology, Vol. 16, No. 1, 52, 21.04.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ICC-dementia (International Centenarian Consortium - dementia)
T2 - An international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups
AU - Brodaty, Henry
AU - Woolf, Claudia
AU - Andersen, Stacy
AU - Barzilai, Nir
AU - Brayne, Carol
AU - Cheung, Karen Siu Lan
AU - Corrada, Maria M.
AU - Crawford, John D.
AU - Daly, Catriona
AU - Gondo, Yasuyuki
AU - Hagberg, Bo
AU - Hirose, Nobuyoshi
AU - Holstege, Henne
AU - Kawas, Claudia
AU - Kaye, Jeffrey
AU - Kochan, Nicole A.
AU - Lau, Bobo Hi Po
AU - Lucca, Ugo
AU - Marcon, Gabriella
AU - Martin, Peter
AU - Poon, Leonard W.
AU - Richmond, Robyn
AU - Robine, Jean Marie
AU - Skoog, Ingmar
AU - Slavin, Melissa J.
AU - Szewieczek, Jan
AU - Tettamanti, Mauro
AU - Viña, José
AU - Perls, Thomas
AU - Sachdev, Perminder S.
PY - 2016/4/21
Y1 - 2016/4/21
N2 - Background: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary aim is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. Methods: Studies focusing on individuals aged ≥95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. Discussion: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments.
AB - Background: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary aim is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. Methods: Studies focusing on individuals aged ≥95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. Discussion: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments.
KW - Centenarians
KW - Dementia
KW - Incidence
KW - International
KW - Prevalence
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=84963823343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963823343&partnerID=8YFLogxK
U2 - 10.1186/s12883-016-0569-4
DO - 10.1186/s12883-016-0569-4
M3 - Article
C2 - 27098177
AN - SCOPUS:84963823343
VL - 16
JO - BMC Neurology
JF - BMC Neurology
SN - 1471-2377
IS - 1
M1 - 52
ER -