Hypnosis as a modulator of cellular immune dysregulation during acute stress

Janice K. Kiecolt-Glaser, Phillip Marucha, Cathie Atkinson, Ronald Glaser

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

To assess the influence Of a hypnotic intervention on cellular immune function during a commonplace stressful event, the authors selected 33 medical and dental students on the basis of hypnotic susceptibility. Initial blood samples were obtained during a lower stress period, and a second sample was drawn 3 days before the first major exam of the term. Half of the participants were randomly assigned to hypnotic-relaxation training in the interval between samples. Participants in the hypnotic group were, on average, protected from the stress-related decrements that were observed in control participants' proliferative responses to 2 mitogens, percentages of CD3+ and CD4+ T-lymphocytes, and interleukin 1 production by peripheral blood leukocytes. More frequent hypnotic-relaxation practice was associated with higher percentages of CD3+ and CD4+ T-lymphocytes. These data provide encouraging evidence that interventions may reduce the immunological dysregulation associated with acute stressors.

Original languageEnglish (US)
Pages (from-to)674-682
Number of pages9
JournalJournal of Consulting and Clinical Psychology
Volume69
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

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Hypnosis
Hypnotics and Sedatives
T-Lymphocytes
Dental Students
Medical Students
Interleukin-1
Mitogens
Leukocytes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Hypnosis as a modulator of cellular immune dysregulation during acute stress. / Kiecolt-Glaser, Janice K.; Marucha, Phillip; Atkinson, Cathie; Glaser, Ronald.

In: Journal of Consulting and Clinical Psychology, Vol. 69, No. 4, 2001, p. 674-682.

Research output: Contribution to journalArticle

Kiecolt-Glaser, Janice K. ; Marucha, Phillip ; Atkinson, Cathie ; Glaser, Ronald. / Hypnosis as a modulator of cellular immune dysregulation during acute stress. In: Journal of Consulting and Clinical Psychology. 2001 ; Vol. 69, No. 4. pp. 674-682.
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