Hyperbaric oxygen therapy ameliorates stress-impaired dermal wound healing

Praveen K. Gajendrareddy, Chandan K. Sen, Michael P. Horan, Phillip Marucha

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Psychological stress has been shown to dysregulate healing in both humans and animals. Studies indicate the possibility for decreased oxygen supply, and increased oxygen demand, in the wounds of the stressed animals. Oxygen is an important mediator of wound healing, and its availability can limit healing rate. Hence, in a mouse model of stress-impaired healing, the hypothesis that hyperbaric oxygen therapy would ameliorate the effect of stress on dermal wound healing was tested. Hyperbaric oxygen therapy (HBO) twice a day during early wound healing significantly ameliorated the effects of stress, bringing healing to near-control levels. There was no significant effect of HBO on the wounds of control animals. Wound inducible nitric oxide synthase (iNOS), modulated by psychological stress and oxygen balance, was studied for gene expression by real-time PCR. Expression of iNOS increased in stressed mice on days 1 (205%; p

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalBrain, Behavior, and Immunity
Volume19
Issue number3
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Hyperbaric Oxygenation
Wound Healing
Oxygen
Skin
Nitric Oxide Synthase Type II
Psychological Stress
Wounds and Injuries
Real-Time Polymerase Chain Reaction
Gene Expression

Keywords

  • Cutaneous healing
  • Hyperbaric oxygen therapy
  • Hypoxia
  • Inducible nitric oxide synthase
  • Inflammation
  • Nitric oxide
  • Oxygen
  • Stress
  • Wound healing

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Hyperbaric oxygen therapy ameliorates stress-impaired dermal wound healing. / Gajendrareddy, Praveen K.; Sen, Chandan K.; Horan, Michael P.; Marucha, Phillip.

In: Brain, Behavior, and Immunity, Vol. 19, No. 3, 05.2005, p. 217-222.

Research output: Contribution to journalArticle

Gajendrareddy, Praveen K. ; Sen, Chandan K. ; Horan, Michael P. ; Marucha, Phillip. / Hyperbaric oxygen therapy ameliorates stress-impaired dermal wound healing. In: Brain, Behavior, and Immunity. 2005 ; Vol. 19, No. 3. pp. 217-222.
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