Human transfer factor activity in the guinea pig: Absence of antigen specificity

Arthur A. Vandenbark; Denis R. Burger; R. Mark Vetto

doi:10.1016/0090-1229(77)90086-1

Human transfer factor activity in the guinea pig: Absence of antigen specificity

Arthur A. Vandenbark, Denis R. Burger, R. Mark Vetto

Neurology

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13 Scopus citations

Abstract

Human transfer factor of known antigen specificity was used to induce skin-test reactivity in strain 13 guinea pigs. This reactivity is reproducible, is dependent upon preexposure of the animal to subsensitizing doses of antigen, persists for at least 14 weeks, and is reflected in some cases by antigen-induced lymphocyte transformation. The skin test response in guinea pigs does not reflect the antigen reactivities of the human TF donor; this suggests that in guinea pigs the TF may augment a low level of sensitization produced during the priming step.

Original language	English (US)
Pages (from-to)	7-16
Number of pages	10
Journal	Clinical Immunology and Immunopathology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/0090-1229(77)90086-1
State	Published - Jul 1977

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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abstract = "Human transfer factor of known antigen specificity was used to induce skin-test reactivity in strain 13 guinea pigs. This reactivity is reproducible, is dependent upon preexposure of the animal to subsensitizing doses of antigen, persists for at least 14 weeks, and is reflected in some cases by antigen-induced lymphocyte transformation. The skin test response in guinea pigs does not reflect the antigen reactivities of the human TF donor; this suggests that in guinea pigs the TF may augment a low level of sensitization produced during the priming step.",

author = "Vandenbark, {Arthur A.} and Burger, {Denis R.} and Vetto, {R. Mark}",

year = "1977",

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AU - Vetto, R. Mark

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AB - Human transfer factor of known antigen specificity was used to induce skin-test reactivity in strain 13 guinea pigs. This reactivity is reproducible, is dependent upon preexposure of the animal to subsensitizing doses of antigen, persists for at least 14 weeks, and is reflected in some cases by antigen-induced lymphocyte transformation. The skin test response in guinea pigs does not reflect the antigen reactivities of the human TF donor; this suggests that in guinea pigs the TF may augment a low level of sensitization produced during the priming step.

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Human transfer factor activity in the guinea pig: Absence of antigen specificity

Abstract

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