Human transfer factor activity in the guinea pig: Absence of antigen specificity

Arthur A. Vandenbark, Denis R. Burger, R. Mark Vetto

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Human transfer factor of known antigen specificity was used to induce skin-test reactivity in strain 13 guinea pigs. This reactivity is reproducible, is dependent upon preexposure of the animal to subsensitizing doses of antigen, persists for at least 14 weeks, and is reflected in some cases by antigen-induced lymphocyte transformation. The skin test response in guinea pigs does not reflect the antigen reactivities of the human TF donor; this suggests that in guinea pigs the TF may augment a low level of sensitization produced during the priming step.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalClinical Immunology and Immunopathology
Volume8
Issue number1
DOIs
StatePublished - Jul 1977

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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