Human sex-chromosome-specific repeats within a region of pseudoautosomal/Yq homology

Elizabeth M.C. Fisher, Tiina Alitalo, Shiuh Wen Luoh, Albert de la Chapelle, David C. Page

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Several categories of human X-Y homologous DNA sequences have been recognized. We report that a locus (DXYS77) approximately 14 kb distal to the pseudoautosomal boundary (PAB) is 93% identical in nucleotide sequence to a locus (DYS148) on the long arm of the Y chromosome (Yq). Within this segment of pseudoautosomal/Yq homology we identified a member of a family of repeats that are concentrated in Xp22.3 and in the euchromatic portion of the Y chromosome. The repeat sequence structure-a dimer bounded by short terminal repeats-is reminiscent of retroposons derived from RNA polymerase III transcripts.

Original languageEnglish (US)
Pages (from-to)625-628
Number of pages4
Issue number4
StatePublished - Aug 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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