Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

A. Ullrich; J. R. Bell; E. Y. Chen; R. Herrera; L. M. Petruzzelli; T. J. Dull; A. Gray; L. Coussens; Y. C. Liao; M. Tsubokawa; A. Mason; P. H. Seeburg; C. Grunfeld; O. M. Rosen; J. Ramachandran

doi:10.1038/313756a0

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

A. Ullrich, J. R. Bell, E. Y. Chen, R. Herrera, L. M. Petruzzelli, T. J. Dull, A. Gray, L. Coussens, Y. C. Liao, M. Tsubokawa, A. Mason, P. H. Seeburg, C. Grunfeld, O. M. Rosen, J. Ramachandran

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1758 Scopus citations

Abstract

We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.

Original language	English (US)
Pages (from-to)	756-761
Number of pages	6
Journal	Nature
Volume	313
Issue number	6005
DOIs	https://doi.org/10.1038/313756a0
State	Published - 1985
Externally published	Yes

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title = "Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes",

abstract = "We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.",

author = "A. Ullrich and Bell, {J. R.} and Chen, {E. Y.} and R. Herrera and Petruzzelli, {L. M.} and Dull, {T. J.} and A. Gray and L. Coussens and Liao, {Y. C.} and M. Tsubokawa and A. Mason and Seeburg, {P. H.} and C. Grunfeld and Rosen, {O. M.} and J. Ramachandran",

year = "1985",

doi = "10.1038/313756a0",

language = "English (US)",

volume = "313",

pages = "756--761",

journal = "Nature",

issn = "0028-0836",

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TY - JOUR

T1 - Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

AU - Ullrich, A.

AU - Bell, J. R.

AU - Chen, E. Y.

AU - Herrera, R.

AU - Petruzzelli, L. M.

AU - Dull, T. J.

AU - Gray, A.

AU - Coussens, L.

AU - Liao, Y. C.

AU - Tsubokawa, M.

AU - Mason, A.

AU - Seeburg, P. H.

AU - Grunfeld, C.

AU - Rosen, O. M.

AU - Ramachandran, J.

PY - 1985

Y1 - 1985

N2 - We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.

AB - We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.

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U2 - 10.1038/313756a0

DO - 10.1038/313756a0

M3 - Article

C2 - 2983222

AN - SCOPUS:0021985413

SN - 0028-0836

VL - 313

SP - 756

EP - 761

JO - Nature

JF - Nature

IS - 6005

ER -

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

Abstract

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