Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

A. Ullrich, J. R. Bell, E. Y. Chen, R. Herrera, L. M. Petruzzelli, T. J. Dull, A. Gray, Lisa Coussens, Y. C. Liao, M. Tsubokawa, A. Mason, P. H. Seeburg, C. Grunfeld, O. M. Rosen, J. Ramachandran

Research output: Contribution to journalArticle

1427 Citations (Scopus)

Abstract

We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.

Original languageEnglish (US)
Pages (from-to)756-761
Number of pages6
JournalNature
Volume313
Issue number6005
DOIs
StatePublished - 1985
Externally publishedYes

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Oncogenes
Protein-Tyrosine Kinases
Amino Acid Sequence
src Genes
Enzyme Precursors
Oncogene Proteins
Sequence Homology
Epidermal Growth Factor Receptor
Complementary DNA
Clone Cells
human INSR protein

ASJC Scopus subject areas

  • General

Cite this

Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L. M., Dull, T. J., ... Ramachandran, J. (1985). Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature, 313(6005), 756-761. https://doi.org/10.1038/313756a0

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. / Ullrich, A.; Bell, J. R.; Chen, E. Y.; Herrera, R.; Petruzzelli, L. M.; Dull, T. J.; Gray, A.; Coussens, Lisa; Liao, Y. C.; Tsubokawa, M.; Mason, A.; Seeburg, P. H.; Grunfeld, C.; Rosen, O. M.; Ramachandran, J.

In: Nature, Vol. 313, No. 6005, 1985, p. 756-761.

Research output: Contribution to journalArticle

Ullrich, A, Bell, JR, Chen, EY, Herrera, R, Petruzzelli, LM, Dull, TJ, Gray, A, Coussens, L, Liao, YC, Tsubokawa, M, Mason, A, Seeburg, PH, Grunfeld, C, Rosen, OM & Ramachandran, J 1985, 'Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes', Nature, vol. 313, no. 6005, pp. 756-761. https://doi.org/10.1038/313756a0
Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzelli LM, Dull TJ et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature. 1985;313(6005):756-761. https://doi.org/10.1038/313756a0
Ullrich, A. ; Bell, J. R. ; Chen, E. Y. ; Herrera, R. ; Petruzzelli, L. M. ; Dull, T. J. ; Gray, A. ; Coussens, Lisa ; Liao, Y. C. ; Tsubokawa, M. ; Mason, A. ; Seeburg, P. H. ; Grunfeld, C. ; Rosen, O. M. ; Ramachandran, J. / Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. In: Nature. 1985 ; Vol. 313, No. 6005. pp. 756-761.
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AU - Dull, T. J.

AU - Gray, A.

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AU - Mason, A.

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AU - Rosen, O. M.

AU - Ramachandran, J.

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