How well do we manage the odontogenic keratocyst? A multicenter study

Brian Kinard, Gentry Hansen, Marshall Newman, Peter Dennis, Tyler Haeffs, Sebastian Perez, Aya Hamao-Sakamoto, Martin Steed, Pamela Hughes, Meredith August, Shelly Abramowicz

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to answer the following clinical questions: Among patients treated for odontogenic keratocysts (OKCs), what is the overall 5-year disease-free rate, and what factors are associated with disease recurrence? Study Design: We implemented a multicenter retrospective cohort study composed of patients presenting for the evaluation and management of previously untreated OKCs. The predictor variables were grouped into demographic, medical, radiographic, and operative categories. The primary outcome variable was time to lesion recurrence. Data analyses were performed by using bivariate analysis and univariate or multivariate Cox proportional hazards models. Results: The study sample was composed of 231 OKCs. Of these, 57 (24.7%) were treated with decompression with residual cystectomy, 86 (37.2%) with enucleation without adjuvant therapy, and 78 (33.8%) with enucleation with peripheral ostectomy. There were 44 recurrences (19%), with a median time to recurrence of 26.7 months (range 15.8–49.8). Conclusions: This multicenter study is the largest study analyzing disease recurrence after treatment of OKCs by using appropriate statistical analysis for a time-to-event outcome (disease recurrence). The 5-year disease-free estimate was 29%. Mandibular lesions, multilocular lesions, and lesions treated with decompression and residual cystectomy were associated with recurrence.

Original languageEnglish (US)
Pages (from-to)282-288
Number of pages7
JournalOral surgery, oral medicine, oral pathology and oral radiology
Volume127
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Odontogenic Cysts
Multicenter Studies
Recurrence
Cystectomy
Decompression
Proportional Hazards Models
Cohort Studies
Retrospective Studies
Demography
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

Kinard, B., Hansen, G., Newman, M., Dennis, P., Haeffs, T., Perez, S., ... Abramowicz, S. (2019). How well do we manage the odontogenic keratocyst? A multicenter study. Oral surgery, oral medicine, oral pathology and oral radiology, 127(4), 282-288. https://doi.org/10.1016/j.oooo.2018.12.001

How well do we manage the odontogenic keratocyst? A multicenter study. / Kinard, Brian; Hansen, Gentry; Newman, Marshall; Dennis, Peter; Haeffs, Tyler; Perez, Sebastian; Hamao-Sakamoto, Aya; Steed, Martin; Hughes, Pamela; August, Meredith; Abramowicz, Shelly.

In: Oral surgery, oral medicine, oral pathology and oral radiology, Vol. 127, No. 4, 01.04.2019, p. 282-288.

Research output: Contribution to journalArticle

Kinard, B, Hansen, G, Newman, M, Dennis, P, Haeffs, T, Perez, S, Hamao-Sakamoto, A, Steed, M, Hughes, P, August, M & Abramowicz, S 2019, 'How well do we manage the odontogenic keratocyst? A multicenter study', Oral surgery, oral medicine, oral pathology and oral radiology, vol. 127, no. 4, pp. 282-288. https://doi.org/10.1016/j.oooo.2018.12.001
Kinard, Brian ; Hansen, Gentry ; Newman, Marshall ; Dennis, Peter ; Haeffs, Tyler ; Perez, Sebastian ; Hamao-Sakamoto, Aya ; Steed, Martin ; Hughes, Pamela ; August, Meredith ; Abramowicz, Shelly. / How well do we manage the odontogenic keratocyst? A multicenter study. In: Oral surgery, oral medicine, oral pathology and oral radiology. 2019 ; Vol. 127, No. 4. pp. 282-288.
@article{4f7be6008b194ef38be65715acd9e99c,
title = "How well do we manage the odontogenic keratocyst? A multicenter study",
abstract = "Objective: The aim of this study was to answer the following clinical questions: Among patients treated for odontogenic keratocysts (OKCs), what is the overall 5-year disease-free rate, and what factors are associated with disease recurrence? Study Design: We implemented a multicenter retrospective cohort study composed of patients presenting for the evaluation and management of previously untreated OKCs. The predictor variables were grouped into demographic, medical, radiographic, and operative categories. The primary outcome variable was time to lesion recurrence. Data analyses were performed by using bivariate analysis and univariate or multivariate Cox proportional hazards models. Results: The study sample was composed of 231 OKCs. Of these, 57 (24.7{\%}) were treated with decompression with residual cystectomy, 86 (37.2{\%}) with enucleation without adjuvant therapy, and 78 (33.8{\%}) with enucleation with peripheral ostectomy. There were 44 recurrences (19{\%}), with a median time to recurrence of 26.7 months (range 15.8–49.8). Conclusions: This multicenter study is the largest study analyzing disease recurrence after treatment of OKCs by using appropriate statistical analysis for a time-to-event outcome (disease recurrence). The 5-year disease-free estimate was 29{\%}. Mandibular lesions, multilocular lesions, and lesions treated with decompression and residual cystectomy were associated with recurrence.",
author = "Brian Kinard and Gentry Hansen and Marshall Newman and Peter Dennis and Tyler Haeffs and Sebastian Perez and Aya Hamao-Sakamoto and Martin Steed and Pamela Hughes and Meredith August and Shelly Abramowicz",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.oooo.2018.12.001",
language = "English (US)",
volume = "127",
pages = "282--288",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - How well do we manage the odontogenic keratocyst? A multicenter study

AU - Kinard, Brian

AU - Hansen, Gentry

AU - Newman, Marshall

AU - Dennis, Peter

AU - Haeffs, Tyler

AU - Perez, Sebastian

AU - Hamao-Sakamoto, Aya

AU - Steed, Martin

AU - Hughes, Pamela

AU - August, Meredith

AU - Abramowicz, Shelly

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Objective: The aim of this study was to answer the following clinical questions: Among patients treated for odontogenic keratocysts (OKCs), what is the overall 5-year disease-free rate, and what factors are associated with disease recurrence? Study Design: We implemented a multicenter retrospective cohort study composed of patients presenting for the evaluation and management of previously untreated OKCs. The predictor variables were grouped into demographic, medical, radiographic, and operative categories. The primary outcome variable was time to lesion recurrence. Data analyses were performed by using bivariate analysis and univariate or multivariate Cox proportional hazards models. Results: The study sample was composed of 231 OKCs. Of these, 57 (24.7%) were treated with decompression with residual cystectomy, 86 (37.2%) with enucleation without adjuvant therapy, and 78 (33.8%) with enucleation with peripheral ostectomy. There were 44 recurrences (19%), with a median time to recurrence of 26.7 months (range 15.8–49.8). Conclusions: This multicenter study is the largest study analyzing disease recurrence after treatment of OKCs by using appropriate statistical analysis for a time-to-event outcome (disease recurrence). The 5-year disease-free estimate was 29%. Mandibular lesions, multilocular lesions, and lesions treated with decompression and residual cystectomy were associated with recurrence.

AB - Objective: The aim of this study was to answer the following clinical questions: Among patients treated for odontogenic keratocysts (OKCs), what is the overall 5-year disease-free rate, and what factors are associated with disease recurrence? Study Design: We implemented a multicenter retrospective cohort study composed of patients presenting for the evaluation and management of previously untreated OKCs. The predictor variables were grouped into demographic, medical, radiographic, and operative categories. The primary outcome variable was time to lesion recurrence. Data analyses were performed by using bivariate analysis and univariate or multivariate Cox proportional hazards models. Results: The study sample was composed of 231 OKCs. Of these, 57 (24.7%) were treated with decompression with residual cystectomy, 86 (37.2%) with enucleation without adjuvant therapy, and 78 (33.8%) with enucleation with peripheral ostectomy. There were 44 recurrences (19%), with a median time to recurrence of 26.7 months (range 15.8–49.8). Conclusions: This multicenter study is the largest study analyzing disease recurrence after treatment of OKCs by using appropriate statistical analysis for a time-to-event outcome (disease recurrence). The 5-year disease-free estimate was 29%. Mandibular lesions, multilocular lesions, and lesions treated with decompression and residual cystectomy were associated with recurrence.

UR - http://www.scopus.com/inward/record.url?scp=85061669985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061669985&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2018.12.001

DO - 10.1016/j.oooo.2018.12.001

M3 - Article

VL - 127

SP - 282

EP - 288

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 4

ER -