How to submit a nail specimen

Erica Reinig, Phoebe Rich, Curtis T. Thompson

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The scarcity of specific submission protocols for nail unit biopsies presents many challenges for appropriate specimen processing. Many nail biopsies are received fragmented or without orientation, often resulting in less-than-ideal tissue embedding and poor histologic sections, which are difficult to interpret. Methods are described for proper nail matrix/bed biopsy and plate submission that incorporate aspects of previous submission protocols and include inking the biopsy specimen along with submitting the tissue on a drawing of the nail. Also described is a technique for maintaining adherence of nail plate to glass slides, a chronic challenge in the laboratory.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalDermatologic Clinics
Issue number2
StatePublished - Apr 1 2015


  • Biopsy
  • Cassette
  • Formalin
  • Histology
  • Microscopy
  • Orientation
  • Sectioning
  • Tissue

ASJC Scopus subject areas

  • Dermatology


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