Hot atom chemistry and radiopharmaceuticals

Kenneth Krohn, Stephen M. Moerlein, Jeanne Link, Michael J. Welch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The chemical products made in a cyclotron target are a combined result of the chemical effects of the nuclear transformation that made the radioactive atom and the bulk radiolysis in the target. This review uses some well-known examples to understand how hot atom chemistry explains the primary products from a nuclear reaction and then how radiation chemistry is exploited to set up the optimal product for radiosynthesis. It also addresses the chemical effects of nuclear decay. There are important principles that are common to hot atom chemistry and radiopharmaceutical chemistry. Both emphasize short-lived radionuclides and manipulation of high specific activity nuclides. Furthermore, they both rely on radiochromatographic separation for identification of no-carrieradded products.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages3-15
Number of pages13
Volume1509
DOIs
StatePublished - 2012
Externally publishedYes
Event14th International Workshop on Targetry and Target Chemistry, WTTC 2012 - Playa del Carmen, Mexico
Duration: Aug 26 2012Aug 29 2012

Other

Other14th International Workshop on Targetry and Target Chemistry, WTTC 2012
CountryMexico
CityPlaya del Carmen
Period8/26/128/29/12

Fingerprint

hot atoms
chemistry
chemical effects
products
nuclear transformations
radiation chemistry
nuclides
radiolysis
nuclear reactions
radioactive isotopes
cyclotrons
manipulators
decay
atoms

Keywords

  • Hot atom chemistry
  • Nucleogenesis
  • Radiation chemistry
  • Radiopharmaceuticals

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Krohn, K., Moerlein, S. M., Link, J., & Welch, M. J. (2012). Hot atom chemistry and radiopharmaceuticals. In AIP Conference Proceedings (Vol. 1509, pp. 3-15) https://doi.org/10.1063/1.4773930

Hot atom chemistry and radiopharmaceuticals. / Krohn, Kenneth; Moerlein, Stephen M.; Link, Jeanne; Welch, Michael J.

AIP Conference Proceedings. Vol. 1509 2012. p. 3-15.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Krohn, K, Moerlein, SM, Link, J & Welch, MJ 2012, Hot atom chemistry and radiopharmaceuticals. in AIP Conference Proceedings. vol. 1509, pp. 3-15, 14th International Workshop on Targetry and Target Chemistry, WTTC 2012, Playa del Carmen, Mexico, 8/26/12. https://doi.org/10.1063/1.4773930
Krohn K, Moerlein SM, Link J, Welch MJ. Hot atom chemistry and radiopharmaceuticals. In AIP Conference Proceedings. Vol. 1509. 2012. p. 3-15 https://doi.org/10.1063/1.4773930
Krohn, Kenneth ; Moerlein, Stephen M. ; Link, Jeanne ; Welch, Michael J. / Hot atom chemistry and radiopharmaceuticals. AIP Conference Proceedings. Vol. 1509 2012. pp. 3-15
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