Hormonal regulation of POMC gene expression in pituitary

J. L. Roberts, James Lundblad, J. H. Eberwine, R. T. Fremeau, S. R J Salton, M. Blum

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The regultion of the POMC gene in the anterior pituitary corticotroph is complex, involving both positive and negative modulators. CRH has been shown to positively regulate POMC gene transcription in a manner analogous to other peptide hormones, mediated through specific regions in the 5' flanking portion of the POMC gene. The effects of hormonal manipulation on POMC gene expression occurred not only at the level of transcription but also at the cellular level. Adrenalectomy was shown to increase the number of cells in the anterior lobe that were actively transcribing the POMC gene, when analyzed by intervening sequence in-situ hybridization. Thus this would suggest that the hormonal effects on POMC gene transcription can be elicited through direct interaction of cells already transcribing the POMC gene as well as through the modulation of the number of cells transcribing the POMC gene.

Original languageEnglish (US)
Pages (from-to)275-285
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume512
StatePublished - 1987
Externally publishedYes

Fingerprint

Pro-Opiomelanocortin
Gene Expression Regulation
Gene expression
Genes
Transcription
Cell Count
Corticotrophs
Gene Expression
Gene
Peptide Hormones
5' Flanking Region
Adrenalectomy
Cell Communication
Introns
Modulators
In Situ Hybridization
Modulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Roberts, J. L., Lundblad, J., Eberwine, J. H., Fremeau, R. T., Salton, S. R. J., & Blum, M. (1987). Hormonal regulation of POMC gene expression in pituitary. Annals of the New York Academy of Sciences, 512, 275-285.

Hormonal regulation of POMC gene expression in pituitary. / Roberts, J. L.; Lundblad, James; Eberwine, J. H.; Fremeau, R. T.; Salton, S. R J; Blum, M.

In: Annals of the New York Academy of Sciences, Vol. 512, 1987, p. 275-285.

Research output: Contribution to journalArticle

Roberts, JL, Lundblad, J, Eberwine, JH, Fremeau, RT, Salton, SRJ & Blum, M 1987, 'Hormonal regulation of POMC gene expression in pituitary', Annals of the New York Academy of Sciences, vol. 512, pp. 275-285.
Roberts JL, Lundblad J, Eberwine JH, Fremeau RT, Salton SRJ, Blum M. Hormonal regulation of POMC gene expression in pituitary. Annals of the New York Academy of Sciences. 1987;512:275-285.
Roberts, J. L. ; Lundblad, James ; Eberwine, J. H. ; Fremeau, R. T. ; Salton, S. R J ; Blum, M. / Hormonal regulation of POMC gene expression in pituitary. In: Annals of the New York Academy of Sciences. 1987 ; Vol. 512. pp. 275-285.
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