Hodgkin Lymphoma and the Microenvironment

Michael Cascio, Y. Natkunam

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hodgkin lymphoma (HL) is a maLignant neoplasm derived from germinal center B-cells. The histopathologic findings in HL are unique in that the neoplastic cells are relatively few in number and can be obscured by large numbers of nonneoplastic cells, including lymphocytes, macrophages, plasma cells, eosinophils, and fibroblasts. The microenvironment encompasses all of the inflammatory cells, fibroblasts, blood vessels, and cytokines found within the vicinity of the neoplastic cell population. The relationship between the tumor cell population and the microenvironment is critical for tumor growth and survival. The pecuLiar histopathologic findings of HL have lead investigators to study the role of the microenvironment with respect to disease pathogenesis and cLinical outcomes. Herein, we review the role of the microenvironment of HL and its relationship to disease pathogenesis through the modulation of host cell response. We conclude with a brief description of new therapeutics targeting molecules in the microenvironment.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Pages1701-1712
Number of pages12
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
DOIs
StatePublished - Jan 1 2014

Fingerprint

Hodgkin Disease
Fibroblasts
Cellular Microenvironment
Neoplasms
Germinal Center
Plasma Cells
Eosinophils
Population
Blood Vessels
B-Lymphocytes
Cell Count
Macrophages
Research Personnel
Lymphocytes
Cytokines
Growth
Therapeutics

Keywords

  • Epstein-Barr virus
  • Galectin-3
  • Hodgkin lymphoma
  • Microenvironment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cascio, M., & Natkunam, Y. (2014). Hodgkin Lymphoma and the Microenvironment. In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (pp. 1701-1712). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386456-7.04108-3

Hodgkin Lymphoma and the Microenvironment. / Cascio, Michael; Natkunam, Y.

Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., 2014. p. 1701-1712.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cascio, M & Natkunam, Y 2014, Hodgkin Lymphoma and the Microenvironment. in Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., pp. 1701-1712. https://doi.org/10.1016/B978-0-12-386456-7.04108-3
Cascio M, Natkunam Y. Hodgkin Lymphoma and the Microenvironment. In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc. 2014. p. 1701-1712 https://doi.org/10.1016/B978-0-12-386456-7.04108-3
Cascio, Michael ; Natkunam, Y. / Hodgkin Lymphoma and the Microenvironment. Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., 2014. pp. 1701-1712
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