HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells

Amy S. Heinzel, Jeff E. Grotzke, Rebecca A. Lines, Deborah A. Lewinsohn, Andria L. McNabb, Daniel N. Streblow, Veronique M. Brand, Heather J. Grieser, John T. Belisle, David M. Lewinsohn

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.

Original languageEnglish (US)
Pages (from-to)1473-1481
Number of pages9
JournalJournal of Experimental Medicine
Volume196
Issue number11
DOIs
StatePublished - Dec 2 2002

Keywords

  • CD8-positive T lymphocytes
  • HLA-E
  • Human
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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