Abstract
Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.
Original language | English (US) |
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Pages (from-to) | 1473-1481 |
Number of pages | 9 |
Journal | Journal of Experimental Medicine |
Volume | 196 |
Issue number | 11 |
DOIs | |
State | Published - Dec 2 2002 |
Keywords
- CD8-positive T lymphocytes
- HLA-E
- Human
- Mycobacterium tuberculosis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology