HIV-1-induced AIDS in monkeys

Theodora Hatziioannou, Gregory Q. Del Prete, Brandon F. Keele, Jacob Estes, Matthew W. McNatt, Julia Bitzegeio, Alice Raymond, Anthony Rodriguez, Fabian Schmidt, C. Mac Trubey, Jeremy Smedley, Michael Piatak, Vineet N. KewalRamani, Jeffrey D. Lifson, Paul D. Bieniasz

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection.

Original languageEnglish (US)
Pages (from-to)1401-1405
Number of pages5
JournalScience
Volume344
Issue number6190
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Haplorhini
HIV-1
Macaca
Acquired Immunodeficiency Syndrome
Viral Tropism
Primate Lentiviruses
Zoonoses
Infection
HIV Infections
Animal Models
T-Lymphocytes
Phenotype
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Hatziioannou, T., Del Prete, G. Q., Keele, B. F., Estes, J., McNatt, M. W., Bitzegeio, J., ... Bieniasz, P. D. (2014). HIV-1-induced AIDS in monkeys. Science, 344(6190), 1401-1405. https://doi.org/10.1126/science.1250761

HIV-1-induced AIDS in monkeys. / Hatziioannou, Theodora; Del Prete, Gregory Q.; Keele, Brandon F.; Estes, Jacob; McNatt, Matthew W.; Bitzegeio, Julia; Raymond, Alice; Rodriguez, Anthony; Schmidt, Fabian; Mac Trubey, C.; Smedley, Jeremy; Piatak, Michael; KewalRamani, Vineet N.; Lifson, Jeffrey D.; Bieniasz, Paul D.

In: Science, Vol. 344, No. 6190, 01.01.2014, p. 1401-1405.

Research output: Contribution to journalArticle

Hatziioannou, T, Del Prete, GQ, Keele, BF, Estes, J, McNatt, MW, Bitzegeio, J, Raymond, A, Rodriguez, A, Schmidt, F, Mac Trubey, C, Smedley, J, Piatak, M, KewalRamani, VN, Lifson, JD & Bieniasz, PD 2014, 'HIV-1-induced AIDS in monkeys', Science, vol. 344, no. 6190, pp. 1401-1405. https://doi.org/10.1126/science.1250761
Hatziioannou T, Del Prete GQ, Keele BF, Estes J, McNatt MW, Bitzegeio J et al. HIV-1-induced AIDS in monkeys. Science. 2014 Jan 1;344(6190):1401-1405. https://doi.org/10.1126/science.1250761
Hatziioannou, Theodora ; Del Prete, Gregory Q. ; Keele, Brandon F. ; Estes, Jacob ; McNatt, Matthew W. ; Bitzegeio, Julia ; Raymond, Alice ; Rodriguez, Anthony ; Schmidt, Fabian ; Mac Trubey, C. ; Smedley, Jeremy ; Piatak, Michael ; KewalRamani, Vineet N. ; Lifson, Jeffrey D. ; Bieniasz, Paul D. / HIV-1-induced AIDS in monkeys. In: Science. 2014 ; Vol. 344, No. 6190. pp. 1401-1405.
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