HIV-1-induced AIDS in monkeys

Theodora Hatziioannou, Gregory Q. Del Prete, Brandon F. Keele, Jacob D. Estes, Matthew W. McNatt, Julia Bitzegeio, Alice Raymond, Anthony Rodriguez, Fabian Schmidt, C. Mac Trubey, Jeremy Smedley, Michael Piatak, Vineet N. KewalRamani, Jeffrey D. Lifson, Paul D. Bieniasz

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55 Scopus citations

Abstract

Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection.

Original languageEnglish (US)
Pages (from-to)1401-1405
Number of pages5
JournalScience
Volume344
Issue number6190
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

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    Hatziioannou, T., Del Prete, G. Q., Keele, B. F., Estes, J. D., McNatt, M. W., Bitzegeio, J., Raymond, A., Rodriguez, A., Schmidt, F., Mac Trubey, C., Smedley, J., Piatak, M., KewalRamani, V. N., Lifson, J. D., & Bieniasz, P. D. (2014). HIV-1-induced AIDS in monkeys. Science, 344(6190), 1401-1405. https://doi.org/10.1126/science.1250761