HIV-1 dynamics in children

Ann J. Melvin, Allen G. Rodrigo, Kathleen M. Mohan, Paul Lewis, Laura Manns-Arcuino, Robert W. Coombs, James I. Mullins, Lisa M. Frenkel

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

HIV-1-infected children have higher plasma viral loads and progress to disease more quickly than infected adults. To gain insight into the accelerated pathogenesis of HIV-1 in children, viral dynamics were measured following the initiation of highly active antiretroviral therapy (HAART) and compared with those reported for adults. A biphasic decline in plasma HIV-1 RNA was observed, with a rapid decrease during the first 1 to 2 weeks of therapy (phase I) followed by a slower decline (phase II). The phase I and II decay rates were not significantly different among children of different ages, pretherapy plasma HIV-1 RNA levels, or CD4 cell counts. Estimated phase I decay rates were similar to those previously reported in adults with a mean of 0.43 days-1 and a half-life of 1.6 days. The phase II decay rates were slower in children compared with adults with a mean of 0.016 days-1 versus 0.066 days-1, and a half-life of 43.3 versus 14.1 days, respectively (p

Original languageEnglish (US)
Pages (from-to)468-473
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume20
Issue number5
StatePublished - Apr 15 1999

Fingerprint

HIV-1
Half-Life
RNA
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
Viral Load
Therapeutics

Keywords

  • Pediatrics
  • Viral dynamics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Melvin, A. J., Rodrigo, A. G., Mohan, K. M., Lewis, P., Manns-Arcuino, L., Coombs, R. W., ... Frenkel, L. M. (1999). HIV-1 dynamics in children. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 20(5), 468-473.

HIV-1 dynamics in children. / Melvin, Ann J.; Rodrigo, Allen G.; Mohan, Kathleen M.; Lewis, Paul; Manns-Arcuino, Laura; Coombs, Robert W.; Mullins, James I.; Frenkel, Lisa M.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 20, No. 5, 15.04.1999, p. 468-473.

Research output: Contribution to journalArticle

Melvin, AJ, Rodrigo, AG, Mohan, KM, Lewis, P, Manns-Arcuino, L, Coombs, RW, Mullins, JI & Frenkel, LM 1999, 'HIV-1 dynamics in children', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 20, no. 5, pp. 468-473.
Melvin AJ, Rodrigo AG, Mohan KM, Lewis P, Manns-Arcuino L, Coombs RW et al. HIV-1 dynamics in children. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1999 Apr 15;20(5):468-473.
Melvin, Ann J. ; Rodrigo, Allen G. ; Mohan, Kathleen M. ; Lewis, Paul ; Manns-Arcuino, Laura ; Coombs, Robert W. ; Mullins, James I. ; Frenkel, Lisa M. / HIV-1 dynamics in children. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1999 ; Vol. 20, No. 5. pp. 468-473.
@article{1fb03ee403ae42dcb8ef33d05801bac6,
title = "HIV-1 dynamics in children",
abstract = "HIV-1-infected children have higher plasma viral loads and progress to disease more quickly than infected adults. To gain insight into the accelerated pathogenesis of HIV-1 in children, viral dynamics were measured following the initiation of highly active antiretroviral therapy (HAART) and compared with those reported for adults. A biphasic decline in plasma HIV-1 RNA was observed, with a rapid decrease during the first 1 to 2 weeks of therapy (phase I) followed by a slower decline (phase II). The phase I and II decay rates were not significantly different among children of different ages, pretherapy plasma HIV-1 RNA levels, or CD4 cell counts. Estimated phase I decay rates were similar to those previously reported in adults with a mean of 0.43 days-1 and a half-life of 1.6 days. The phase II decay rates were slower in children compared with adults with a mean of 0.016 days-1 versus 0.066 days-1, and a half-life of 43.3 versus 14.1 days, respectively (p",
keywords = "Pediatrics, Viral dynamics",
author = "Melvin, {Ann J.} and Rodrigo, {Allen G.} and Mohan, {Kathleen M.} and Paul Lewis and Laura Manns-Arcuino and Coombs, {Robert W.} and Mullins, {James I.} and Frenkel, {Lisa M.}",
year = "1999",
month = "4",
day = "15",
language = "English (US)",
volume = "20",
pages = "468--473",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - HIV-1 dynamics in children

AU - Melvin, Ann J.

AU - Rodrigo, Allen G.

AU - Mohan, Kathleen M.

AU - Lewis, Paul

AU - Manns-Arcuino, Laura

AU - Coombs, Robert W.

AU - Mullins, James I.

AU - Frenkel, Lisa M.

PY - 1999/4/15

Y1 - 1999/4/15

N2 - HIV-1-infected children have higher plasma viral loads and progress to disease more quickly than infected adults. To gain insight into the accelerated pathogenesis of HIV-1 in children, viral dynamics were measured following the initiation of highly active antiretroviral therapy (HAART) and compared with those reported for adults. A biphasic decline in plasma HIV-1 RNA was observed, with a rapid decrease during the first 1 to 2 weeks of therapy (phase I) followed by a slower decline (phase II). The phase I and II decay rates were not significantly different among children of different ages, pretherapy plasma HIV-1 RNA levels, or CD4 cell counts. Estimated phase I decay rates were similar to those previously reported in adults with a mean of 0.43 days-1 and a half-life of 1.6 days. The phase II decay rates were slower in children compared with adults with a mean of 0.016 days-1 versus 0.066 days-1, and a half-life of 43.3 versus 14.1 days, respectively (p

AB - HIV-1-infected children have higher plasma viral loads and progress to disease more quickly than infected adults. To gain insight into the accelerated pathogenesis of HIV-1 in children, viral dynamics were measured following the initiation of highly active antiretroviral therapy (HAART) and compared with those reported for adults. A biphasic decline in plasma HIV-1 RNA was observed, with a rapid decrease during the first 1 to 2 weeks of therapy (phase I) followed by a slower decline (phase II). The phase I and II decay rates were not significantly different among children of different ages, pretherapy plasma HIV-1 RNA levels, or CD4 cell counts. Estimated phase I decay rates were similar to those previously reported in adults with a mean of 0.43 days-1 and a half-life of 1.6 days. The phase II decay rates were slower in children compared with adults with a mean of 0.016 days-1 versus 0.066 days-1, and a half-life of 43.3 versus 14.1 days, respectively (p

KW - Pediatrics

KW - Viral dynamics

UR - http://www.scopus.com/inward/record.url?scp=0033561273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033561273&partnerID=8YFLogxK

M3 - Article

C2 - 10225229

AN - SCOPUS:0033561273

VL - 20

SP - 468

EP - 473

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 5

ER -