High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients

Chitra N. Sambasivan, Nicholas R. Kunio, Prakash V. Nair, Karen A. Zink, Joel E. Michalek, John B. Holcomb, Martin Schreiber

    Research output: Contribution to journalArticle

    58 Citations (Scopus)

    Abstract

    Background: Administration of high transfusion ratios in patients not requiring massive transfusion might be harmful. We aimed to determine the effect of high ratios of fresh frozen plasma (FFP) and platelets (PLT) to packed red blood cells (PRBC) in nonmassively transfused patients. Methods: Records of 1,788 transfused trauma patients who received 1:2 ratio of FFP:PRBCs or a >1:2 ratio PLT:PRBCs had significantly decreased ICU-free days and ventilator-free days. Conclusions: FFP:PRBC and PLT:PRBC ratios were not associated with in-hospital mortality. Depending on the threshold analyzed, a high ratio of FFP:PRBC and PLT:PRBC transfusion was associated with fewer ICU-free days and fewer ventilator-free days, suggesting that the damage control infusion of FFP and PLT may cause increased morbidity in nonmassively transfused patients and should be rapidly terminated when it becomes clear that a massive transfusion will not be required.

    Original languageEnglish (US)
    JournalJournal of Trauma - Injury, Infection and Critical Care
    Volume71
    Issue number2 SUPPL. 3
    DOIs
    StatePublished - Aug 2011

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    Blood Platelets
    Erythrocytes
    Mortality
    Mechanical Ventilators
    Erythrocyte Transfusion
    Hospital Mortality
    Morbidity
    Wounds and Injuries

    Keywords

    • Nonmassive transfusion
    • Risks of transfusion
    • Transfusion ratios

    ASJC Scopus subject areas

    • Surgery
    • Critical Care and Intensive Care Medicine

    Cite this

    High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients. / Sambasivan, Chitra N.; Kunio, Nicholas R.; Nair, Prakash V.; Zink, Karen A.; Michalek, Joel E.; Holcomb, John B.; Schreiber, Martin.

    In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 71, No. 2 SUPPL. 3, 08.2011.

    Research output: Contribution to journalArticle

    Sambasivan, Chitra N. ; Kunio, Nicholas R. ; Nair, Prakash V. ; Zink, Karen A. ; Michalek, Joel E. ; Holcomb, John B. ; Schreiber, Martin. / High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients. In: Journal of Trauma - Injury, Infection and Critical Care. 2011 ; Vol. 71, No. 2 SUPPL. 3.
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    AU - Zink, Karen A.

    AU - Michalek, Joel E.

    AU - Holcomb, John B.

    AU - Schreiber, Martin

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