High glucose levels do not directly impair cellular binding of HDL3 or HDL-mediated efflux of cholesterol from human skin fibroblasts

P. B. Duell, E. L. Bierman

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The excess risk of atherosclerosis that is associated with diabetes mellitus cannot be completely accounted for by other known risk factors. Recent studies have suggested that increased glycation of high density lipoproteins (HDL) at high glucose concentrations causes functional abnormalities that might contribute to accelerated atherosclerosis. Other investigators also have shown that elevated glucose concentrations can stimulate the activity of protein kinase C in cultured cells. Because protein kinase C appears to be involved in HDL receptor-mediated efflux, the hypothesis that a high glucose concentration in vitro might modulate HDL-mediated efflux of cholesterol from human fibroblasts was tested. These studies indicate that a high glucose level alone does not affect the interaction of normal HDL3 with cultured human skin fibroblasts.

Original languageEnglish (US)
Pages (from-to)174-178
Number of pages5
JournalActa Diabetologica
Volume28
Issue number2
DOIs
StatePublished - Jun 1 1991

Keywords

  • Cholesterol efflux
  • Cultured cells
  • Diabetes mellitus
  • HDL
  • Hyperglycaemia

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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