High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion

Kristen L. Zuloaga, Lance A. Johnson, Natalie E. Roese, Tessa Marzulla, Wenri Zhang, Xiao Nie, Farah N. Alkayed, Christine Hong, Marjorie Grafe, Martin Pike, Jacob Raber, Nabil Alkayed

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Diabetes causes endothelial dysfunction and increases the risk of vascular cognitive impairment. However, it is unknown whether diabetes causes cognitive impairment due to reductions in cerebral blood flow or through independent effects on neuronal function and cognition. We addressed this using right unilateral common carotid artery occlusion to model vascular cognitive impairment and long-term high-fat diet to model type 2 diabetes in mice. Cognition was assessed using novel object recognition task, Morris water maze, and contextual and cued fear conditioning. Cerebral blood flow was assessed using arterial spin labeling magnetic resonance imaging. Vascular cognitive impairment mice showed cognitive deficit in the novel object recognition task, decreased cerebral blood flow in the right hemisphere, and increased glial activation in white matter and hippocampus. Mice fed a high-fat diet displayed deficits in the novel object recognition task, Morris water maze and fear conditioning tasks and neuronal loss, but no impairments in cerebral blood flow. Compared to vascular cognitive impairment mice fed a low fat diet, vascular cognitive impairment mice fed a high-fat diet exhibited reduced cued fear memory, increased deficit in the Morris water maze, neuronal loss, glial activation, and global decrease in cerebral blood flow. We conclude that high-fat diet and chronic hypoperfusion impair cognitive function by different mechanisms, although they share commons features, and that high-fat diet exacerbates vascular cognitive impairment pathology.

Original languageEnglish (US)
Pages (from-to)1257-1270
Number of pages14
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Cerebrovascular Circulation
High Fat Diet
Blood Vessels
Cognition
Fear
Neuroglia
Water
Fat-Restricted Diet
Common Carotid Artery
Memory Disorders
Cognitive Dysfunction
Type 2 Diabetes Mellitus
Hippocampus
Magnetic Resonance Imaging
Pathology
Recognition (Psychology)

Keywords

  • cerebral blood flow
  • chronic cerebral hypoperfusion
  • cognitive impairment
  • diabetes
  • high-fat diet
  • Vascular cognitive impairment
  • vascular dementia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion. / Zuloaga, Kristen L.; Johnson, Lance A.; Roese, Natalie E.; Marzulla, Tessa; Zhang, Wenri; Nie, Xiao; Alkayed, Farah N.; Hong, Christine; Grafe, Marjorie; Pike, Martin; Raber, Jacob; Alkayed, Nabil.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 36, No. 7, 01.07.2016, p. 1257-1270.

Research output: Contribution to journalArticle

Zuloaga, Kristen L. ; Johnson, Lance A. ; Roese, Natalie E. ; Marzulla, Tessa ; Zhang, Wenri ; Nie, Xiao ; Alkayed, Farah N. ; Hong, Christine ; Grafe, Marjorie ; Pike, Martin ; Raber, Jacob ; Alkayed, Nabil. / High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion. In: Journal of Cerebral Blood Flow and Metabolism. 2016 ; Vol. 36, No. 7. pp. 1257-1270.
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