High-dose ifosfamide and etoposide with filgrastim for stem cell mobilization in patients with advanced ovarian cancer

M. L. Donato, D. Gershenson, C. Ippoliti, J. T. Wharton, R. C. Bast, A. Aleman, P. Anderlini, J. G. Gajewski, S. Giralt, J. Molldrem, N. Ueno, J. Lauppe, M. Korbling, J. Boyer, D. Bodurka-Bevers, M. Bevers, T. Burke, R. Freedman, C. Levenback, J. WolfR. E. Champlin

    Research output: Contribution to journalArticle

    8 Scopus citations

    Abstract

    High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation has shown promise as treatment for recurrent or persistent epithelial ovarian cancer. We evaluated the stem cell mobilization regimen of high-dose ifosfamide plus etoposide in 32 patients with epithelial ovarian cancer, who had a positive second-look laparatomy or recurrent disease. Ifosfamide was given at 10 g/m2 by continuous i.v. from days 1 to 3. Etoposide was given at 150 mg/m2 every 12 h for six doses on days 1-3. Filgrastim was given at 10 μg/kg/d s.c. from day 5 until the completion of peripheral blood stem cell harvest. Fourteen of 32 patients had measurable or evaluable disease before mobilization therapy and were assessed for response. In nine (64%) of the 14 patients, treatment response was demonstrated, and these patients received a second cycle of mobilization therapy. The target CD34+ cell dose (> 8 x 106 cells/kg) was achieved with a median of one apheresis (range 1-5). A median of 25.1 (range 8.0-122.5) x 106 CD34+ cells/kg body weight was collected. Non-hematologic toxicity was limited to grade 2 renal dysfunction in one patient and grade 2 hepatic dysfunction in three patients. In this patient group, high-dose ifosfamide plus etoposide with filgrastim support was well tolerated, lead to successful stem cell harvest and had antitumor activity.

    Original languageEnglish (US)
    Pages (from-to)1137-1140
    Number of pages4
    JournalBone marrow transplantation
    Volume25
    Issue number11
    DOIs
    StatePublished - Jan 1 2000

      Fingerprint

    Keywords

    • Etoposide
    • Ifosfamide
    • Ovarian cancer
    • Stem cell collection

    ASJC Scopus subject areas

    • Hematology
    • Transplantation

    Cite this

    Donato, M. L., Gershenson, D., Ippoliti, C., Wharton, J. T., Bast, R. C., Aleman, A., Anderlini, P., Gajewski, J. G., Giralt, S., Molldrem, J., Ueno, N., Lauppe, J., Korbling, M., Boyer, J., Bodurka-Bevers, D., Bevers, M., Burke, T., Freedman, R., Levenback, C., ... Champlin, R. E. (2000). High-dose ifosfamide and etoposide with filgrastim for stem cell mobilization in patients with advanced ovarian cancer. Bone marrow transplantation, 25(11), 1137-1140. https://doi.org/10.1038/sj.bmt.1702421