TY - JOUR
T1 - High- and low-dose fentanyl anaesthesia
T2 - Hormonal and metabolic responses during cholecystectomy
AU - Giesecke, K.
AU - Hamberger, B.
AU - Järnberg, P. O.
AU - Klingstedt, C.
AU - Persson, B.
N1 - Funding Information:
This investigation was supported by grants from Medical Research Council (No. 02330).
PY - 1988/11
Y1 - 1988/11
N2 - We have compared two groups of patients given low- or highdose fentanyl anaesthesia. Arterial blood samples were collected for measurement of glucose, free fatty acids (FFA), glycerol, betahydroxy-butyrate, insulin, c-peptide, glucagon, human growth hormone (HGH), cortisol and adrenaline concentrations. After induction of anaesthesia, blood concentrations of most of these substances decreased. After the start of surgery the concentrations of cortisol, glucose, HGH, FFA and beta-hydroxy-butyrate increased significantly in the group anaesthetized with the lower dose of fentanyl. In the group that received high-dose fentanyl anaesthesia the plasma concentrations of almost all the hormones and substances measured remained relatively low. The differences between the two groups during surgery were significant for adrenaline (P < 0.001) and cortisol (P < 0.001). High-dose fentanyl appears to block the trauma-induced stress response seen in patients anaesthetized with low dose fentanyl.
AB - We have compared two groups of patients given low- or highdose fentanyl anaesthesia. Arterial blood samples were collected for measurement of glucose, free fatty acids (FFA), glycerol, betahydroxy-butyrate, insulin, c-peptide, glucagon, human growth hormone (HGH), cortisol and adrenaline concentrations. After induction of anaesthesia, blood concentrations of most of these substances decreased. After the start of surgery the concentrations of cortisol, glucose, HGH, FFA and beta-hydroxy-butyrate increased significantly in the group anaesthetized with the lower dose of fentanyl. In the group that received high-dose fentanyl anaesthesia the plasma concentrations of almost all the hormones and substances measured remained relatively low. The differences between the two groups during surgery were significant for adrenaline (P < 0.001) and cortisol (P < 0.001). High-dose fentanyl appears to block the trauma-induced stress response seen in patients anaesthetized with low dose fentanyl.
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U2 - 10.1093/bja/61.5.575
DO - 10.1093/bja/61.5.575
M3 - Article
C2 - 3207528
AN - SCOPUS:0023732335
SN - 0007-0912
VL - 61
SP - 575
EP - 582
JO - British journal of anaesthesia
JF - British journal of anaesthesia
IS - 5
ER -