High- and low-dose fentanyl anaesthesia: Hormonal and metabolic responses during cholecystectomy

K. Giesecke, B. Hamberger, Per-Olof Järnberg, C. Klingstedt, B. Persson

Research output: Contribution to journalArticle

50 Scopus citations


We have compared two groups of patients given low- or highdose fentanyl anaesthesia. Arterial blood samples were collected for measurement of glucose, free fatty acids (FFA), glycerol, betahydroxy-butyrate, insulin, c-peptide, glucagon, human growth hormone (HGH), cortisol and adrenaline concentrations. After induction of anaesthesia, blood concentrations of most of these substances decreased. After the start of surgery the concentrations of cortisol, glucose, HGH, FFA and beta-hydroxy-butyrate increased significantly in the group anaesthetized with the lower dose of fentanyl. In the group that received high-dose fentanyl anaesthesia the plasma concentrations of almost all the hormones and substances measured remained relatively low. The differences between the two groups during surgery were significant for adrenaline (P <0.001) and cortisol (P <0.001). High-dose fentanyl appears to block the trauma-induced stress response seen in patients anaesthetized with low dose fentanyl.

Original languageEnglish (US)
Pages (from-to)575-582
Number of pages8
JournalBritish Journal of Anaesthesia
Issue number5
Publication statusPublished - Nov 1988
Externally publishedYes


ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

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