Hierarchies of transcriptional regulation during liver regeneration

Svitlana Kurinna, Michelle Craig Barton

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

The remarkable capacity of the liver to regenerate after severe injury or disease has excited interest for centuries. The goal of harnessing this process in treatment of liver disease, and the appreciation of the parallels between regeneration and tumor development in the liver, remain a major driver for research in this area. Studies of liver regeneration as a model system offer a view of intricate and precisely timed regulatory pathways that drive the process toward completion. Successful regeneration of the liver mass demands a hierarchal and well-controlled balance between proliferative and metabolic functions, which is orchestrated by signaling and regulation of transcription factors. Control and regulation of these cascades of transcriptional activities, necessary for induction, renewal, and cessation of liver growth, are the focus of this chapter.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages201-227
Number of pages27
EditionC
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
NumberC
Volume97
ISSN (Print)1877-1173

Keywords

  • Early response genes
  • Exocrine
  • Extracellular matrix
  • Hypoxia
  • Immediate-early genes
  • MicroRNAs
  • Nuclear receptors
  • Paracrine
  • Partial hepatectomy

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Hierarchies of transcriptional regulation during liver regeneration'. Together they form a unique fingerprint.

Cite this