Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands

Val J. Watts, Cindy P. Lawler, Timm Knoerzer, Mechelle A. Mayleben, Kim A. Neve, David E. Nichols, Richard B. Mailman

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We report that certain substituted hexathydrobenzo[a]phenanthridines are novel high affinity ligands selective for the dopamine D3 receptor. These data demonstrate that substitutions on the heterocyclic nitrogen and the pendant phenyl ring of this nucleus cause a marked increase in both affinity and selectivity for dopamine D3 vs. D2 receptors. Thus, these compounds represent important new tools to study the pharmacology of dopamine D3 receptors, and may also provide an opportunity for the synthesis of new radioligands for dopamine D3 receptors.

Original languageEnglish (US)
Pages (from-to)271-273
Number of pages3
JournalEuropean Journal of Pharmacology
Volume239
Issue number1-3
DOIs
StatePublished - Aug 3 1993

Keywords

  • Dihydrexidine
  • Dopamine D receptors
  • Dopamine D receptors

ASJC Scopus subject areas

  • Pharmacology

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    Watts, V. J., Lawler, C. P., Knoerzer, T., Mayleben, M. A., Neve, K. A., Nichols, D. E., & Mailman, R. B. (1993). Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands. European Journal of Pharmacology, 239(1-3), 271-273. https://doi.org/10.1016/0014-2999(93)91012-C