Heritability of serum sodium concentration: Evidence for sex- and ethnic-specific effects

Beth Wilmot, V. Saroja Voruganti, Yen Pei C Chang, Yi Fu, Zhan Chen, Herman A. Taylor, James G. Wilson, Teresa Gipson, Vallabh O. Shah, Jason G. Umans, Michael F. Flessner, Robert Hitzemann, Alan R. Shuldiner, Anthony G. Comuzzie, Shannon McWeeney, Philip G. Zager, Jean W. Maccluer, Shelley A. Cole, David Cohen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Serum sodium concentration is the clinical index of systemic water balance. Although disordered water balance is common and morbid, little is known about genetic effects on serum sodium concentration at the population level. Prior studies addressed only participants of European descent and either failed to demonstrate significant heritability or showed only modest effect. We investigated heritability of serum sodium concentration in large cohorts reflecting a range of races/ethnicities, including the Framingham Heart Study (FHS, non-Hispanic Caucasian), the Heredity and Phenotype Intervention Heart Study (HAPI, Amish Caucasian), the Jackson Heart Study (JHS, African American), the Strong Heart Family Study (SHFS, American Indian), and the Genetics of Kidney Disease in Zuni Indians Study (GKDZI, American Indian). Serum sodium was transformed for the osmotic effect of glucose, and participants with markedly elevated glucose or reduced estimated glomerular filtration rate (eGFR) were excluded. Using a standard variance components method, incorporating covariates of age, glucose, and eGFR, we found heritability to be high in African American and American Indian populations and much more modest in non-Hispanic Caucasian populations. Estimates among females increased after stratification on sex and were suggestive among female participants in FHS (0.18 ± 0.12, P = 0.057) and male participants in JHS (0.24 ± 0.16, P = 0.067) and statistically significant among female participants in JHS (0.44 ± 0.09, P = 1 × 10 -7), SHFS (0.59 ± 0.05, P = 9.4 × 10 -46), and GKDZI (0.46 ± 0.15, P = 1.7 × 10 -4), and male participants in HAPI (0.18 ± 0.12, P = 0.03) and SHFS (0.67 ± 0.07, P = 5.4 × 10 -26). Exclusion of diuretic users increased heritability among females and was significant in all cohorts where data were available. In aggregate, these data strongly support the heritability of systemic water balance and underscore sex and ethnicity-specific effects.

Original languageEnglish (US)
Pages (from-to)220-228
Number of pages9
JournalPhysiological Genomics
Volume44
Issue number3
DOIs
StatePublished - Feb 2012

Fingerprint

North American Indians
Sodium
Serum
Glomerular Filtration Rate
Glucose
African Americans
Water
Amish
Population
Inborn Genetic Diseases
Heredity
Kidney Diseases
Diuretics
Phenotype

Keywords

  • Hypernatremia
  • Hyponatremia
  • Osmoregulation
  • Water balance

ASJC Scopus subject areas

  • Physiology
  • Genetics

Cite this

Heritability of serum sodium concentration : Evidence for sex- and ethnic-specific effects. / Wilmot, Beth; Saroja Voruganti, V.; Chang, Yen Pei C; Fu, Yi; Chen, Zhan; Taylor, Herman A.; Wilson, James G.; Gipson, Teresa; Shah, Vallabh O.; Umans, Jason G.; Flessner, Michael F.; Hitzemann, Robert; Shuldiner, Alan R.; Comuzzie, Anthony G.; McWeeney, Shannon; Zager, Philip G.; Maccluer, Jean W.; Cole, Shelley A.; Cohen, David.

In: Physiological Genomics, Vol. 44, No. 3, 02.2012, p. 220-228.

Research output: Contribution to journalArticle

Wilmot, B, Saroja Voruganti, V, Chang, YPC, Fu, Y, Chen, Z, Taylor, HA, Wilson, JG, Gipson, T, Shah, VO, Umans, JG, Flessner, MF, Hitzemann, R, Shuldiner, AR, Comuzzie, AG, McWeeney, S, Zager, PG, Maccluer, JW, Cole, SA & Cohen, D 2012, 'Heritability of serum sodium concentration: Evidence for sex- and ethnic-specific effects', Physiological Genomics, vol. 44, no. 3, pp. 220-228. https://doi.org/10.1152/physiolgenomics.00153.2011
Wilmot, Beth ; Saroja Voruganti, V. ; Chang, Yen Pei C ; Fu, Yi ; Chen, Zhan ; Taylor, Herman A. ; Wilson, James G. ; Gipson, Teresa ; Shah, Vallabh O. ; Umans, Jason G. ; Flessner, Michael F. ; Hitzemann, Robert ; Shuldiner, Alan R. ; Comuzzie, Anthony G. ; McWeeney, Shannon ; Zager, Philip G. ; Maccluer, Jean W. ; Cole, Shelley A. ; Cohen, David. / Heritability of serum sodium concentration : Evidence for sex- and ethnic-specific effects. In: Physiological Genomics. 2012 ; Vol. 44, No. 3. pp. 220-228.
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