Heritability of fearful-anxious endophenotypes in infant rhesus macaques

A preliminary report

Douglas E. Williamson, Kristine Coleman, Silviu Alin Bacanu, Bernie J. Devlin, Jeffrey Rogers, Neal D. Ryan, Judy L. Cameron

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    Abstract

    Background: Research efforts to discover the genetic underpinnings of anxiety and depression is challenging because of the etiologic heterogeneity inherent to these disorders. These efforts might be aided by the study of related behavioral phenotypes in model organisms, such as monkeys. Methods: Eighty-five rhesus monkeys (Macaca mulatta) from the Oregon National Primate Research Center were drawn from a standard matriarchal colony and tested for behavioral response in four testing paradigms designed to elicit fearful-anxious reactions. Heritabilities were estimated using variance component-based quantitative genetic analyses with much of the genetic information arising from paternal half-sibs. Results: Individual behaviors reflecting increased distress responses (e.g., vocalizations and teeth grinding) and behavioral inhibition (e.g., latency to leave mother, latency to inspect novel fruit) showed significant heritability, even though a small number of monkeys were assessed. Exploratory factor analyses identified seven clusters of behaviors across tests, some of which were found to be heritable. Conclusions: These results indicate that several specific fearful-anxious behaviors in infant rhesus monkeys are heritable within this colony. Accordingly, these phenotypes, which are believed to represent the genetic liability for anxiety and depression, are good candidates for further genetic investigation in this population.

    Original languageEnglish (US)
    Pages (from-to)284-291
    Number of pages8
    JournalBiological Psychiatry
    Volume53
    Issue number4
    DOIs
    StatePublished - Feb 15 2003

    Fingerprint

    Endophenotypes
    Macaca mulatta
    Haplorhini
    Anxiety
    Depression
    Infant Behavior
    Phenotype
    Research
    Primates
    Statistical Factor Analysis
    Fruit
    Tooth
    Mothers
    Population

    Keywords

    • Anxiety
    • Depression
    • Endophenotypes
    • Heritability
    • Model organisms

    ASJC Scopus subject areas

    • Biological Psychiatry

    Cite this

    Williamson, D. E., Coleman, K., Bacanu, S. A., Devlin, B. J., Rogers, J., Ryan, N. D., & Cameron, J. L. (2003). Heritability of fearful-anxious endophenotypes in infant rhesus macaques: A preliminary report. Biological Psychiatry, 53(4), 284-291. https://doi.org/10.1016/S0006-3223(02)01601-3

    Heritability of fearful-anxious endophenotypes in infant rhesus macaques : A preliminary report. / Williamson, Douglas E.; Coleman, Kristine; Bacanu, Silviu Alin; Devlin, Bernie J.; Rogers, Jeffrey; Ryan, Neal D.; Cameron, Judy L.

    In: Biological Psychiatry, Vol. 53, No. 4, 15.02.2003, p. 284-291.

    Research output: Contribution to journalArticle

    Williamson, DE, Coleman, K, Bacanu, SA, Devlin, BJ, Rogers, J, Ryan, ND & Cameron, JL 2003, 'Heritability of fearful-anxious endophenotypes in infant rhesus macaques: A preliminary report', Biological Psychiatry, vol. 53, no. 4, pp. 284-291. https://doi.org/10.1016/S0006-3223(02)01601-3
    Williamson, Douglas E. ; Coleman, Kristine ; Bacanu, Silviu Alin ; Devlin, Bernie J. ; Rogers, Jeffrey ; Ryan, Neal D. ; Cameron, Judy L. / Heritability of fearful-anxious endophenotypes in infant rhesus macaques : A preliminary report. In: Biological Psychiatry. 2003 ; Vol. 53, No. 4. pp. 284-291.
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