Hepatitis B vaccination uptake and correlates of serologic response among HIV-infected and uninfected men who have sex with men (MSM) in Bangkok, Thailand

Wannee Chonwattana, Boonyos Raengsakulrach, Timothy H. Holtz, Punneeporn Wasinrapee, Jaray Tongtoyai, Supaporn Chaikummao, Sarika Pattanasin, Janet M. McNicholl, Frits van Griensven, Marcel Curlin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: Vaccination against hepatitis B virus (HBV) is recommended for all HBV-susceptible men who have sex with men (MSM). There is limited information on correlates of immunity to HBV vaccination in this group. We present serologic response rates to hepatitis B vaccine and identify factors associated with impaired response among HIV-uninfected and HIV-infected Thai MSM. Methodology: HBV-susceptible volunteers were offered hepatitis B vaccination at months zero, one, and six. We measured baseline (pre-vaccination) total serum IgG and IgG subclasses (all participants), baseline CD4 count, and plasma HIV-1 viral load (PVL) (HIV+ participants). HBV serologies were retested at 12 months. Serologic responses were compared between all groups in men receiving three vaccine doses. Results: 511/651 HIV-negative and 64/84 HIV-positive participants completed the three-dose series. Response rates in HIV-uninfected and -infected participants were 90.1% vs. 50.0% (p 1550. mg/dL and PVL >10,000 copies/mL were almost always non-responsive (p

Original languageEnglish (US)
JournalVaccine
DOIs
StateAccepted/In press - May 15 2015
Externally publishedYes

Keywords

  • HBV
  • HIV
  • IgG
  • Plasma viral load
  • Serologic response
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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    Chonwattana, W., Raengsakulrach, B., Holtz, T. H., Wasinrapee, P., Tongtoyai, J., Chaikummao, S., Pattanasin, S., McNicholl, J. M., van Griensven, F., & Curlin, M. (Accepted/In press). Hepatitis B vaccination uptake and correlates of serologic response among HIV-infected and uninfected men who have sex with men (MSM) in Bangkok, Thailand. Vaccine. https://doi.org/10.1016/j.vaccine.2015.11.071