Hepatic lipase (LIPC) promoter polymorphism in men with coronary artery disease: Allele frequency and effects on hepatic lipase activity and plasma HDL-C concentrations

Ralph V. Shohet, Gloria L. Vega, Azam Anwar, Joaquin E. Cigarroa, Scott M. Grundy, Jonathan C. Cohen

    Research output: Contribution to journalArticle

    49 Scopus citations

    Abstract

    Hepatic lipase is an important determinant of plasma HDL concentration and LDL subclass distribution and may therefore influence susceptibility to coronary artery disease (CAD). To assess the effect of genetic variation in hepatic lipase activity on CAD susceptibility, we determined the frequency of the -514T allele of hepatic lipase in white men with CAD and in controls who did not have CAD. In men with CAD, postheparin plasma hepatic lipase activity was 15% to 20% lower in heterozygotes and 30% lower in homozygotes for the - 514T allele. Allele frequencies were similar in cases and controls, however, and were consistent with Hardy-Weinberg expectation in both groups. This finding was confirmed in a second group comprising cases with premature symptomatic CAD and controls who were free of disease. These data indicate that a primary decrease in hepatic lipase activity of as much as 30% does not influence susceptibility to CAD in white men.

    Original languageEnglish (US)
    Pages (from-to)1975-1978
    Number of pages4
    JournalArteriosclerosis, thrombosis, and vascular biology
    Volume19
    Issue number8
    DOIs
    StatePublished - Aug 1999

    Keywords

    • Atherosclerosis
    • HDL
    • Hepatic lipase
    • Polymorphism
    • Risk factor

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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